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Oncogenic KRAS activation is responsible for the most common genetic subtype of lung cancer. Although many of the major downstream signaling pathways that KRAS engages have been defined, these discoveries have yet to translate into effective targeted thera ...
Medical devices have gone a long way since their beginning. In the last decades, the trend has been towards Implanted Medical Devices (IMDs). The technology evolution has provided the necessary tools for longer-term, less invasive devices. Several devices ...
Defining immunogenic domains of viral proteins capable of eliciting a protective immune response is crucial in the development of novel epitope-based prophylactic strategies. This is particularly important for the selective targeting of conserved regions s ...
Background. Robot-aided neurorehabilitation can provide intensive, repetitious training to improve upper-limb function after stroke. To be more effective, motor therapy ought to be progressive and continuously challenge the patient's ability. Current robot ...
This paper presents the concept and initial results of a novel approach for robot assisted sensorimotor training in stroke rehabilitation. It is based on a brain-body-robot interface (B 2RI), combining both neural and physiological recordings, that detects ...
In the past decade, several arm rehabilitation robots have been developed to assist neurological patients during therapy. Early devices were limited in their number of degrees of freedom and range of motion, whereas newer robots such as the ARMin robot can ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder arising from the selective death of motor neurons. Approximately 20% of familial ALS (fALS) cases are caused by toxic gain-of-function mutations in the superoxide dismutase 1 (SOD1) ...
Stroke, or cerebral-vascular accident is the leading cause of disabilities in the western world. It primarily affects mobility due to a degradation of principal motor functions such as balance and gait. This reduction of mobility directly impacts the spect ...
It is a time of great promise and expectation for the applications of knowledge about mechanisms of cancer toward more effective and enduring therapies for human disease. Conceptualizations such as the hallmarks of cancer are providing an organizing princi ...
Today, more than 30 products using a manufacturing process based on mammalian cell culture have been approved for human therapy. Most of these products are currently supplied with stirred tank bioreactors operated in batch or fed-batch mode. However, the b ...