Concept

Mitral stenosis

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Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes

Nahal Mansouri, Sina Nassiri

Mesenchymal stromal/stem cell (MSC) therapy has shown promise in experimental models of idiopathic pulmonary fibrosis (IPF). The aim of this study was to test the therapeutic effects of extracellular vesicles produced by human BM MSCs (MEx) in a bleomycin- ...

AMER SOC CLINICAL INVESTIGATION INC2019

Concealed abnormal atrial phenotype in patients with Brugada syndrome and no history of atrial fibrillation

Jean-Marc Vesin, Adrian Luca, Sasan Yazdani, Lukas Kappenberger

Objectives The electrocardiogram (ECG) of patients with BrS in sinus rhythm might reflect intrinsic atrial electrical abnormalities independent from any previous atrial fibrillation (AF). Aim of this study is to investigate the presence of P-wave abnormali ...

Elsevier2018

Fluid dynamics of an idealized left ventricle: the extended Nitsche's method for the treatment of heart valves as mixed time varying boundary conditions

Alfio Quarteroni, Anna Tagliabue

In this work, we study the blood flow dynamics in idealized left ventricles (LV) of the human heart modelled by the Navier-Stokes equations with mixed time varying boundary conditions. The latter are introduced for simulating the functioning of the aortic ...

Wiley2017

Computational study of the risk of restenosis in coronary bypasses

Alfio Quarteroni, Christian Vergara

Coronary artery disease, caused by the buildup of atherosclerotic plaques in the coronary vessel wall, is one of the leading causes of death in the world. For high-risk patients, coronary artery bypass graft is the preferred treatment. Despite overall exce ...

Springer Heidelberg2017

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Few data are available on the assessment of P-wave beat-to-beat morphology variability and its ability to identify patients prone to paroxysmal atrial fibrillation (AF) occurrence. Aim of this study was to determine whether electrocardiographic (ECG) param ...

Excerpta Medica Inc-Elsevier Science Inc2017

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In spite of the progress in management of Atrial Fibrillation (AF), this arrhythmia is one of the major causes of stroke and heart failure. The progression of this pathology from a silent paroxysmal form (PAF) into a sustained AF can be prevented by predic ...

2017

MATHICSE Technical Report: Fluid dynamics of an idealized left ventricle: the extended Nitsche’s method for the treatment of heart valves as mixed time varying boundary conditions

Alfio Quarteroni, Luca Dede', Anna Tagliabue

In this work, we study the blood flow dynamics in idealized left ventricles (LV)of the human heart modelled by the Navier-Stokes equations with mixed time varying boundary conditions (BCs). The latter are introduced for simulating the functioning of the ao ...

MATHICSE2015

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Background: Left atrial (LA) dilatation is associated with a large variety of cardiac diseases. Current cardiovascular magnetic resonance (CMR) strategies to measure LA volumes are based on multi-breath-hold multi-slice acquisitions, which are time-consumi ...

Taylor & Francis2015

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The computational fluid dynamics of the heart represents a challenging task both in terms of mathematical and numerical modeling; this is mainly due to the pulsatile nature of the blood flow, to its complex interaction with the valves, and, more in general ...

2015

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We propose a biophysical modelling approach to separately investigate the impact of right and left atrial (RA/LA) electrical heterogeneity on atrial fibrillation (AF) perpetuation. The baseline AF substrate was based on a 4:1 anisotropy ratio and uniform m ...

2015