Concept

Targeted drug delivery

Related publications (75)

Free-electron-laser coherent diffraction images of individual drug-carrying liposome particles in solution

Using the excellent performances of a SACLA (RIKEN/HARIMA, Japan) X-ray free electron laser (X-FEL), coherent diffraction imaging (CDI) was used to detect individual liposome particles in water, with or without inserted doxorubicin nanorods. This was possi ...

2018

Polyserotonin Nanoparticles as Multifunctional Materials for Biomedical Applications

Nako Nakatsuka

Serotonin-based nanoparticles represent a class of previously unexplored multifunctional nanoplatforms with potential biomedical applications. Serotonin, under basic conditions, self-assembles into monodisperse nanoparticles via autoxidation of serotonin m ...

2018

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

Harm-Anton Klok, Claudia Battistella

Polymer nanomedicines are very attractive to improve the delivery of chemotherapeutics. Polymer conjugates and other polymer-based nanocarriers allow to increase plasma half-life and drug bioavailability and can also be guided toward tumors using passive a ...

2017

Thermal-responsive biodegradable composite membrane for drug delivery application

Ya Wang

Drug delivery systems have been engineered in order to improve therapeutic performance and reduce the side effects of conventional delivery system like oral ingestion, subcutaneous injection [1-2]. There exist several types of drug delivery systems, among ...

2017

Folic acid on iron oxide nanoparticles: platform with high potential for simultaneous targeting, MRI detection and hyperthermia treatment of lymph node metastases of prostate cancer

Heinrich Hofmann, Josefina Adriana Maria Bastiaansen, Marijana Mionic Ebersold, Débora Bonvin

The overexpression of the folate receptor in most cancers has been widely exploited to specifically deliver folic acid (FA) coupled nanomedicines to tumors. However, complex coupling chemistry is often used to bind FA to the nanoparticles. Furthermore, ver ...

Royal Society of Chemistry2017

High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry

Francesco Stellacci, Li Tang, Ye Yang, Ahmet Bekdemir

Inorganic nanoparticles (NPs) are studied as drug carriers, radiosensitizers and imaging agents, and characterizing nanoparticle biodistribution is essential for evaluating their efficacy and safety. Tracking NPs at the single-cell level with current techn ...

Nature Publishing Group2017

Exosome-inspired targeting of cancer cells with enhanced affinity

Ardalan Hosseini

One of the major challenges in the area of novel drug delivery systems (NDDSs) is finding distinguished ligands for specific receptors represented by many cancer cells in order to enhance their cancer homing efficacy. Exosomes, the so-called natural nanoca ...

Royal Soc Chemistry2016

Magnetic nanoparticle-induced hyperthermia with appropriate payloads: Paul Ehrlich's "magic (nano)bullet" for cancer theranostics?

Heinrich Hofmann, Swati Krishnan

Effective multimodal cancer management requires the optimal integration of diagnostic and therapeutic modalities. Radiation therapy, chemotherapy and immunotherapy, alone or in combination, are integral parts of various cancer treatment protocols. Hyperthe ...

Elsevier2016

Bioorthogonal Oxime Ligation Mediated in vivo Cancer Targeting

Li Tang, Yu Xu

Current cancer targeting relying on specific biological interaction between the cell surface antigen and respective antibody or its analogue has proven to be effective in the treatment of different cancers; however, this strategy has its own limitations, s ...

2015

Innovative optical lactate biosensing through the design of nanostructured materials

Oswaldo Javier Pérez Anguiano

The scope of this thesis is the synthesis of nanostructured materials, their functionalization and use for optical lactate biosensing applications. Rapid detection of L-lactate is important in many applications in the clinical sector, in the food industry, ...

EPFL2015

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