Concept

Aortic regurgitation

Related publications (93)

Structural strain energy function applied to the ageing of the human aorta

Stiffening of the aorta with progressing age leads to decrease of aortic compliance and thus to an increase of pulse pressure amplitude. Using a strain energy function (SEF) which takes into account the composition of the arterial wall, we have studied the ...

2007

Beta-catenin downregulation is required for adaptive cardiac remodeling

The armadillo-related protein beta-catenin has multiple functions in cardiac tissue homeostasis: stabilization of beta-catenin has been implicated in adult cardiac hypertrophy, and downregulation initiates heart formation in embryogenesis. The protein is a ...

2007

The effect of a myocardial infarction on the normalized time-varying elastance curve

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, David Jegger

It has been suggested that the shape of the normalized time-varying elastance curve [E(n)(t(n))] is conserved in different cardiac pathologies. We hypothesize, however, that the E(n)(t(n)) differs quantitatively after myocardial infarction (MI). Sprague-Da ...

2006

Effects of a stiffened arterial tree on ventricular-arterial coupling in healthy and diseased hearts

David Jegger

In this thesis we study ventricular-arterial coupling in rodents under the influence of arterial stiffening and myocardial infarction (MI), combination of the two considered as a novel cardiovascular research model for diseased hearts pumping against an ag ...

EPFL2006

Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice

Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof

Global assessment of both cardiac and arterial function is important for a meaningful interpretation of pathophysiological changes in animal models of cardiovascular disease. We simultaneously acquired left ventricular (LV) and aortic pressure and LV volum ...

2004

An ultrasound-based method for determining pulse wave velocity in superficial arteries

Nikolaos Stergiopoulos

In this paper, we present a method for estimating local pulse wave velocity (PWV) solely from ultrasound measurements: the area-flow (QA) method. With the QA method, PWV is estimated as the ratio between change in flow and change in cross-sectional area (P ...

2004

Arterial elastance and heart-arterial coupling in aortic regurgitation are determined by aortic leak severity

Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof

In aortic valve regurgitation (AR), aortic leak severity modulates left ventricle (LV) arterial system interaction. The aim of this study was to assess (1) how arterial elastance (E(a)), calculated as the ratio of LV end-systolic pressure and stroke volume ...

2002

Estimation of local aortic elastic properties with MRI

Nikolaos Stergiopoulos, Reto Meuli

Aortic compliance and pulse wave velocity (PWV) are important determiners of heart load, and are clinically useful indices of cardiovascular risk. Most direct methods to derive them require invasive pressure measurement. In this work a noninvasive techniqu ...

2002

Granular Segregation as a Critical Phenomenon

Pedro Miguel Nunes Pereira de Almeida Reis

We present the results of an experimental study of patterned segregation in a horizontally shaken shallow layer of a binary mixture of dry particles. An order parameter for the segregated domains is defined and the effect of the variation of the combined f ...

American Physical Society2002

Relation of effective arterial elastance to arterial system properties

Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof

Effective arterial elastance (E(a)), defined as the ratio of left ventricular (LV) end-systolic pressure and stroke volume, lumps the steady and pulsatile components of the arterial load in a concise way. Combined with E(max), the slope of the LV end-systo ...

2002

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