Concept
Receptor antagonist
Related people (22)
Urs von Gunten
URS VON GUNTEN
born in Baden (Switzerland) on 20/10/1959
RESEARCH INTERESTS
Drinking water quality and water treatment. Unit processes and process combinations (adsorption processes, membrane processes, oxidation processes). Chemical oxidation and advanced oxidation processes: kinetics and mechanisms of formation of disinfection by-products and degradation of micropollutants. Assessment of toxicology of of transformation products. Biogeochemical processes in riverbank filtration systems. In situ and out-of-ground treatment of groundwaters
EDUCATION
Diploma Swiss Federal Institute of Technology (ETH) Zürich, Department of Chemistry,Switzerland, 1983
Ph.D.Swiss Federal Institute of Technology (ETH) Zürich, Switzerland, 1989.
AWARDS AND FELLOWSHIPS
2018 Clarivate Analytics Highly Cited Researcher
2015 Thomson Reuters Highly Cited Researcher
2015 Recipient of the Harvey Rosen Award 2015 of the International Ozone Association
2015 Professorship under the Chinese Academy of Sciences President’s International Fellowship Initiative for Distinguished Scientists
2014 Thomson Reuters Highly Cited Researcher
2013 Distinguished Lecturer for AEESP at the American Water Works Association Annual Conference, Denver, June 10, 2013
2012-to date Adjunct Professor at the Gwangju Institute of Science and Technology, Korea
2011 Full Professor at the Swiss Federal Institute of Technology, Lausanne (EPFL)
2010 Adjunct Professor at the State Key Laboratory of Environmental Aquatic
Chemistry, Chinese Academy of Sciences
2010 Adjunct Professor at the Curtin University of Technology, Perth,
Australia
2007 Honorary Professorship at the Harbin Institute of Technology, Harbin,
China
2007 Recipient of the Harvey Rosen Award 2007 of the International Ozone
Association
2007 Environmental Science and Technology Excellence in Review Award
2006 Professor title at ETHZ, Department of Environmental Sciences
2001 Recipient of the Harvey Rosen Award 2001 of the International Ozone
Association
1999 Recipient of the Marteen Schalekamp Award 1999 of the IWSA
1993 Recipient of a short-term fellowship of the Swiss National Science
Foundation in 1993 and 1994
1993 EERO short-term fellowship-holder
PROFESSIONAL RECORD
2013-2016 Head of transdisciplinary project “Regional Water Supply Basel Country 21”, Eawag
2010-2017 Head of Competence Center for Drinking Water, Eawag
2008/2009 Visiting Professor at the Curtin Water Quality Research Centre,
Curtin University of Technology, Perth, Australia
2004-to date Deputy head of department Water Resources and Drinking Water,
Eawag
2004-2008 Head of the cross-cutting project Drinking water for the 21st
century, Eawag
2000 2004 Head of department Water Resources and Drinking Water, Eawag
2000/2001 Sabbatical at University of Colorado, Boulder
1998 - 1999 Head of department of Chemistry, Eawag
1995 - 2011 Lecturer at Swiss Federal Institute of Technology (ETH) Zürich,
Switzerland.
1995- to date Group leader of the drinking water group of the chemistry
department at Eawag
1994/93 Visiting Scientist at the International Research Center for
Water and Environment of Lyonnaise des Eaux (8 months),
CIRSEE, Le Pecq, France
since 1992 Research Scientist at Eawag
1989 - 1991 Postdoctoral Researcher at Eawag
1984 - 1989 Research Assistant, Swiss Federal Institute of Technology,
Zürich
EDITORIAL ACTIVITIES
Associate Editor Environmental Science and Technology (2010/2011)
Guest Editor Water Research for special issue on Emerging
Contaminants (2010)
Guest Editor Journal of water supply: Research and
Technology-Aqua for a special issue on Oxidation Processes (2008)
Member of the editorial board of the journal Ozone: Science and Engineering.
Member of the editorial board of Journal of water supply: Research and Technology-Aqua.
FORMER PROFESSIONAL ACTIVITIES
2016 Co-organizer of PEAK seminar ”Neue Herausforderungen und Lösungsansätze in der Wasserversorgung – Fallbeispiele aus dem Kanton BL”. Dübendorf, November 11, 2016
2015 Organizer of PEAK seminar “Micropollutants in drinking water”, Dübendorf, October 30
2014 Co-organizer of the Eawag Infotag “Wasserversorgung und Uferfiltration – ein System unter Druck?” Dübendorf, September 9, 2014
2014 Co-organizer of a Symposium “Advanced oxidation processes for water treatment” 5th EuCheMS Chemistry Congress 2014, Aug. 31 – Sept. 4, Istanbul, Turkey, 2014
2013 Co-Organizer of PEAK seminar on “Oxidation and Disinfection Processes”, Aug. 30, Dübendorf
2013 Co-Organizer of the Micropoll & Ecohazard Conference, Zürich, June 17-19, 2013
2013 Co-Organizer of the session “Advanced Oxidation – Technologies and Applications, Leading Edge Technology (LET) Conference, Bordeaux, June 2-6, 2013
2011 Co-Organizer of Korean-Swiss Science Days in Zürich “Water for the Future”, ETHZ, November 9-10, 2011.
2010 Co-Organizer of an international symposium “Oxidation processes in natural and technical aquatic systems” in honour of Jürg Hoigné’s 80 birthday, Eawag, May 21, 2010.
2010 Co-Organizer of 23. Mülheimer Wassertechnisches Seminar “Möglichkeiten und Grenzen von oxidativen Prozessen in der Wasserreinhaltung”, March 11, 2010, IWW, Mülheim an der Ruhr
2008 Co-Organizer of the Eawag Infotag 2008 “Vom Gewässer ins Glas”, Sept. 12, 2008, Eawag, Dübendorf
2008 Organizing committee of Leading Edge Technology Conference (LET), Zürich, June 1-4, 2008.
2008 Co-organizer of Sino-Swiss workshop “Water Resources Management and Drinking Water Quality”, Harbin Institute of Technology, Harbin, China, January, 2008
2007 Organizer of Wave21 seminar on “New insights in the field of drinking water treatment”, Dübendorf, Sept. 14, 2007.
2007 Co-organizer of a symposium entitled “Sustainability in Water Supply: Advances in Oxidation Processes for Water Treatment” at ACS Spring conference, Chicago, March 25-29, 2007.
2006 Organizer of Wave21 seminar on “New developments of analytical methods for drinking water analysis”, Dübendorf, Sept. 15, 2006,
2005 Organizer of Wave21 seminar on “New applications of ozone in water treatment”, Sept. 23, 2005, Dübendorf
1999 Co-organizer of 200th Anniversary Symposium in honor of Ch. F. Schönbein - the discoverer of ozone, October 1999, Basel.
1995 Organizer of a symposium in honor of J. Hoigné, June, 1995, Dübendorf, Switzerland
1991 Co-organizer of the workshop "Chemodynamics of Groundwaters", November, 1991, Mont Sainte-Odile, France
Stewart Cole
Professor Stewart Cole is an international authority in bacterial molecular-genetics and genomics. He has made outstanding contributions in several fields including: bacterial anaerobic electron transport; genome analysis of retroviruses and papillomaviruses; antibiotic resistance mechanisms; and the molecular microbiology of toxigenic clostridia. His studies on isoniazid and multidrug resistance in Mycobacterium tuberculosis, together with his pioneering work on the pathogenicity, evolution and genomics of the tubercle and leprosy bacilli, have made him an undisputed leader in the field of mycobacterial research. The findings of his research are of direct relevance to public health and disease-control in both the developing world and the industrialised nations. He has published over 250 scientific papers and review articles, and holds many patents.
Pierre Vogel
BIOGRAPHIE
Professional positions:
P. Vogel was born in Cully (Switzerland) Oct. 23, 1944. In 1969, he did his Ph.D under supervision of Prof. H. Prinzbach at the Institute of Organic Chemistry, University of Lausanne. He spent two years at Yale University, New Haven, Connecticut, USA with Prof. Martin Saunders, Prof. J. A. Berson, K. A. Wiberg and P.v.R. Schleyer (Princeton Universtiy). He worked then as a Research chemist at Syntex S.A., in Mexico with Prof. P.Crabbé before the return to the University of Lausanne in 1973. As of 1977 he became Professor of organic chemistry at the University of Lausanne. In 1991 he was Vice-Chairman of the Institute of organic Chemistry, University of Lausanne until 2001. He was also part-time grad.school teacher at the Universities of Rouen and Caen from 1991 to 1993 and Part-time professor at Ecole Polytechnique de Palaiseau from 1993-2000. Since 2001 he is Professor of organic chemistry at the EPFL.
Degrees and distincions
1969 Ph.D, University of Lausanne
1976 Swiss Chemical Society Award, Werner Medal
1984-1989 IOCD adviser
1988-1989 Associate Professor of Organic Chemistry at Ecole Normale
Supérieure, Paris
1989-2000 Member of the Swiss National Council of Research
1991-1992 Associate Professor of Organic Chemistry, University of Paris VI
1992 Pacific Coast Lecturer (USA)
1992-1993 Associate Professor at the Université de Montpellier, France
1993 Associate Professor, Université Paris Sud, Orsay
1994 (spring) Associate Professor, ESPCI, Paris
1997 President of the european COST D2 management committee
2002-2003 Novartis Lecturer
2004-2005 Boehringer Ingelheim Distinguished Lecturer
Henry Markram
Henry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Tamar Kohn
2014 - present Associate Professor, EPFL and adjunct researcher, Eawag 2007 - 2013 Assistant Professor, EPFL 2004 - 2006 Postdoctoral researcher, UC Berkeley 2000 - 2004 PhD, Environmental Engineering, Johns Hopkins University 1999 Diploma, Environmental Sciences, ETHZ
Patrick Daniel Barth
Professor Patrick Barth is Associate Professor at EPFL and Adjunct Associate Professor at Baylor College of Medicine, Houston, TX, USA. He received training in Physics, Chemistry and Biology (University of Paris, ENS) in France and performed his PhD at the Commissiariat a l'Energie Atomique in Saclay, France on structure/function studies of membrane proteins (photosystem I) using biochemical and biophysical experimental techniques. He carried out postdoctoral studies at University of California at Berkeley with Tom Alber on computational development for calculating protein electrostatics and designing de novo selective peptide inhibitors of cellular protein interactions. He then went to the University of Washington as a postdoctoral fellow and instructor in David Baker's laboratory to develop computational techniques in the software Rosetta for predicting and designing membrane protein structures. He started his independent career and received tenure at Baylor College of Medicine. He will continue at EPFL to marry computation and experiment for understanding the molecular determinants of signal transduction, as well as modeling and designing membrane proteins with novel functions for various synthetic biology and therapeutic applications.