MesopotamiaMesopotamia is a historical region of West Asia situated within the Tigris–Euphrates river system, in the northern part of the Fertile Crescent. Today, Mesopotamia occupies modern Iraq. In the broader sense, the historical region included present-day Iraq and parts of present-day Iran, Kuwait, Syria and Turkey. The Sumerians and Akkadians (including Assyrians and Babylonians), each originating from different areas, dominated Mesopotamia from the beginning of recorded history (3100 BC) to the fall of Babylon in 539 BC, when it was conquered by the Achaemenid Empire.