Concept
Anesthetic
Related publications (27)
Transient brain activity dynamics discriminate levels of consciousness during anesthesia
Dimitri Nestor Alice Van De Ville, Elvira Pirondini, Ayberk Ozkirli
The awake mammalian brain is functionally organized in terms of large-scale distributed networks that are constantly interacting. Loss of consciousness might disrupt this temporal organization leaving patients unresponsive. We hypothesize that characterizi ...
Nature Portfolio2024A Needle-Shaped Electrochemical Sensor in Platinum for Robust Monitoring of Anaesthetics
Sandro Carrara, Federica Barbeni
A needle-shaped electrochemical sensor based on platinum electrodes is proposed in this paper. These platinum electrodes provide improved mechanical properties with respect to previous prototypes proposed in literature. This makes them suitable for inserti ...
IEEE2022A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes
Kathryn Hess Bellwald, Lida Kanari, Martina Scolamiero
Environmental cues influence the highly dynamic morphology of microglia. Strategies to characterize these changes usually involve user-selected morphometric features, which preclude the identification of a spectrum of context-dependent morphological phenot ...
NATURE PORTFOLIO2022Local Emergence of Peregrine Solitons: Experiments and Theory
It has been shown analytically that Peregrine solitons emerge locally from a universal mechanism in the so-called semiclassical limit of the one-dimensional focusing nonlinear Schrodinger equation. Experimentally, this limit corresponds to the strongly non ...
FRONTIERS MEDIA SA2021Pencil Graphite Needle-Shaped Biosensor for Anaesthetic Monitoring in Human Serum
Sandro Carrara, Danilo Demarchi, Simone Aiassa
Direct and online continuous monitoring of anaesthetic intake by the patient's blood stream improves practices in the critical procedure of anaesthesia. Several systems have been proposed to address this challenge. Electrochemical techniques are highly app ...
IEEE2020Chemistry and Analysis of Nanoparticle-Modified Living Cells
Conventional therapeutics are often limited by their targeting ability, resulting in harmful and potential fatal side-effects for the patients. Recently, new strategies have been developed to improve target specificity of drugs in order to generate more ef ...
EPFL2020Live Demonstration: Quasi-Digital Portable Pen to Monitor Anaesthetics Delivery
Sandro Carrara, Danilo Demarchi, Simone Aiassa, Francesco Grassi
The live demonstration presents the innovative concept of a portable pen-device able to sense anaesthetic compounds over time for improved anaesthesiology practice. A custom Printed Circuit Board (PCB) manage in the event-based quasi-digital domain the sam ...
IEEE2019Quasi-Digital Biosensor-Interface for a Portable Pen to Monitor Anaesthetics Delivery
Sandro Carrara, Francesca Stradolini, Danilo Demarchi, Abuduwaili Tuoheti, Simone Aiassa
Monitoring of patient response to the anaesthetic drugs is an attractive improvement for achieving a correct balance of sedation level, increasing the chance of success in the right procedure of anaesthesia. Nowadays, there are no commercial tools able to ...
IEEE2019Gas-phase structures reflect the pain-relief potency of enkephalin peptides
Vladimir Kopysov, Aleksandr Pereverzev
We use cold ion spectroscopy and quantum-chemical computations to solve the structures of opioid peptides enkephalins in the gas phase. The derived structural parameters clearly correlate with the known pharmacological efficiency of the studied drugs, sugg ...
2019Performance of Carbon Nano-Scale Allotropes in Detecting Midazolam and Paracetamol in Undiluted Human Serum
Giovanni De Micheli, Sandro Carrara, Francesca Stradolini, Irene Taurino, Ioulia Tzouvadaki, Nima Aliakbarinodehi, Sattar Akbari Nakhjavani
Nano-materials are highly exploited to enhance sensing performance of electrochemical electrodes by increasing the Electro-Active Surface Area (EASA). In this work, an analytical calculation of the deposited EASA is presented and experimentally validated b ...
2018