Concept
Hashimoto's thyroiditis
Related publications (34)
Cryo-EM structure of native human thyroglobulin
The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of ...
2022First-principles calculations of iodine-related point defects in CsPbI3
Joachim Maier, Alessandro Senocrate
We present here first principles hybrid functional calculations of the atomic and electronic structure of several iodine-related point defects in CsPbI3, a material relevant for photovoltaic applications. We show that the presence of neutral interstitial I ...
2019Memory B Cells Activate Brain-Homing, Autoreactive CD4(+) T Cells in Multiple Sclerosis
Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic, particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic factors contribute to generating an autoreactive CD4(+) T cell repertoire is no ...
CELL PRESS2018Glycotargeting therapeutics
Jeffrey Alan Hubbell, David Scott Wilson
Several embodiments of the present disclosure relate to therapeutic compositions configured to target the liver of a subject and that are useful in the treatment or prevention of one or more of transplant rejection, autoimmune disease, food allergy, and im ...
2018Bioengineering strategies for inducing tolerance in autoimmune diabetes
Jeffrey Alan Hubbell, Steinunn Baekkeskov Hanahan, Edward Allen Phelps
Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have ...
Elsevier Science Bv2017Nanoparticles comprising a metal core surrounded by a monolayer for lymph node targeting
Francesco Stellacci, Ye Yang, Ahmet Bekdemir
Amphiphilic gold nanoparticles (amph-NPs), composed of gold cores surrounded by an amphiphilic mixed organic ligand shell, are capable of embedding within and traversing lipid membranes. Active agent is bound thereto for use in vaccine and other adjuvant t ...
2017