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Auditory verbal hallucinations (AVHs) are a hallmark of schizophrenia and can significantly impair patients' emotional, social, and occupational functioning. Despite progress in psychopharmacology, over 25% of schizophrenia patients suffer from treatment-r ...
Retinal gene therapy could potentially affect the lives of millions of people suffering from blinding disorders. Yet, one of the major hurdles remains the delivery of therapeutic nucleic acids to the retinal target cells. Due to the different barriers that ...
Neuroligins (NLGNs) are cell adhesion molecules that are important for proper synaptic formation and functioning and are critical regulators of the balance between neural excitation/inhibition (E/I). Mutations in NLGNs have been linked to psychiatric disor ...
Endogenous rhythms of circalunar periodicity (similar to 29.5 days) and their underlying molecular and genetic basis have been demonstrated in a number of marine species [1, 2]. In contrast, there is a great deal of folklore but no consistent association o ...
This thesis studies the notion of responsiveness in architectural design. It tries to make a framework for understanding the act of response in architectural body. Focusing on Light as a contextual force, it studies the way light affects the built environm ...
Glacier retreat as a consequence of climate change influences freshwater ecosystems in manifold ways, yet the physical and chemical bases of these effects are poorly studied. Here, we characterize how water temperature differs between alpine lakes with and ...
Evaluating and improving snow models and outflow predictions for hydrological applications is hindered by the lack of continuous data on bulk volumetric liquid water content (θw) and storage capacity of the melting snowpack. The combination of upward looki ...
The appropriate choice of glazing in a facade depends on many factors. They include amongst other criteria: location, orientation, climatic condition, energetic efficiency, usage of the building, required user comfort, and the architectural concept. On the ...
Rapamycin is a drug with antiproliferative and immunosuppressive properties, widely used for prevention of acute graft rejection and cancer therapy. It specifically inhibits the activity of the mammalian target of rapamycin (mTOR), a protein kinase known t ...
Photonic Nanojets are highly localized wave fields emerging directly behind dielectric microspheres; if suitably illuminated. In this contribution we reveal how different illumination conditions can be used to engineer the photonic Nanojets by measuring th ...
