Concept
Molecular medicine
Related publications (13)
Information Theory in Transmembrane Transport
The past decades have seen the advent of information theory in various fields, from quantum physics to cosmology.At an intermediary scale between atomic and cosmological scales are biological systems and in particular the cell, as a constitutive element of ...
EPFL2023The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity
Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...
EPFL2022Toward a mechanistic understanding of variable chromatin modules
Our genome is a long sequence of DNA that contains all the information to be able to constitute a living organism like us, similarly to what the letters in a book do to create a story. This sequence, which is a stretch of molecules called nucleotides, is a ...
EPFL2021Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
Florence Pojer, Kelvin Ka Ching Lau, Oliver Hantschel, Grégory La Sala
The transcription factor STAT3 is frequently activated in human solid and hematological malignancies and remains a challenging therapeutic target with no approved drugs to date. Here, we develop synthetic antibody mimetics, termed monobodies, to interfere ...
2020Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic cancer patient-derived organoid (PDO) library that recapitul ...
2018Host and pathogen genomics of severe pediatric infections
Infectious diseases are among the leading causes of human morbidity and mortality, with the greatest burden felt in the pediatric population. For any infectious disease, only a fraction of the exposed individuals develop clinical symptoms. These inter-indi ...
EPFL2016The Biology/Disease-driven Human Proteome Project (B/D-HPP): Enabling Protein Research for the Life Sciences Community
Martin Kussmann, Ruedi Aebersold
The biology and disease oriented branch of the Human Proteome Project (B/D-HPP) was established by the Human Proteome Organization (HUPO) with the main goal of supporting the broad application of state-of-the-art measurements of proteins and proteomes by l ...
Amer Chemical Soc2013Exploring the mechanisms of metal-based pharmacological agents via an integrated approach
The peculiar chemical properties of metal-based drugs impart innovative pharmacological profiles to this class of therapeutic and diagnostic agents, most likely in relation to novel molecular mechanisms still poorly understood. However, inorganic drugs hav ...
2012Probing Odorant-Mediated Receptor Activation
Molecular interactions of odorants with their olfactory receptors (ORs) are of central importance for the mammalian olfactory system to detect and discriminate a large variety of odors with a limited set of receptors. How a particular OR binds and distingu ...
EPFL2012Single-Cell Analysis of Mycobacterial Persistence Using Microfabricated Tools
Bacterial cells behave as individuals despite being genetically identical and subject to the same environment. Although the underlying mechanisms of cellular individuality are not well understood, temporal variation of gene expression and protein levels in ...
EPFL2012