Concept

Pulmonary hypertension

Related publications (84)

Arterial remodeling using a constituent-based approach

This thesis is intended to contribute to the field of biomechanics of growth and remodeling of arteries. The work focuses particularly on growth and remodeling caused by sustained hypertension, increased blood flow, and ageing. A structure-based constituti ...

EPFL2010

A structure-based model of arterial remodeling in response to sustained hypertension

Nikolaos Stergiopoulos, Alkiviadis Tsamis, Alexander Rachev

A novel structure-based mathematical model of arterial remodeling in response to a sustained increase in pressure is proposed. The model includes two major aspects of remodeling in a healthy matured vessel. First, the deviation of the wall stress and flow- ...

2009

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall

Tyler Nerton Thacher

Due to the pulsatile nature of blood flow, arteries are constantly exposed to dynamic mechanical forces; the pulsatility continuously stretches the vessel wall and the flow creates a frictional force on the interior surface. These stresses, referred to as ...

EPFL2009

RC time constant of single lung equals that of both lungs together: a study in chronic thromboembolic pulmonary hypertension

Nikolaos Stergiopoulos, Nico Westerhof

The product of resistance, R, and compliance, C (RC time), of the entire pulmonary circulation is constant. It is unknown if this constancy holds for individual lungs. We determined R and C in individual lungs in chronic thromboembolic pulmonary hypertensi ...

2009

Arterial remodeling in response to increased blood flow using a constituent-based model

Nikolaos Stergiopoulos, Alkiviadis Tsamis

Previous theoretical models of arterial remodeling in response to changes in blood flow were based on the assumption that material properties of the arterial wall remain unchanged during the remodeling process. According to experimental findings, however, ...

2009

The Role of Atrial Modeling in the Development of ECG Processing Tools

Jean-Marc Vesin, Mathieu Lemay, Laurent Renaud Uldry, Cédric Duchene, Vincent Jacquemet, Lukas Kappenberger

The standard ECG remains the most common non-invasive tool for assessing atrial fibrillation. Specific signal processing techniques have been developed to improve the diagnosis. However, validation of such tools is challenging and comprehensive invasive da ...

2009

Effects of reduced cyclic stretch on vascular smooth muscle cell function of pig carotids perfused ex vivo

Nikolaos Stergiopoulos, Paolo Silacci, Tyler Nerton Thacher, Veronica Gambillara

With advancing age arteries stiffen, reducing arterial compliance and leading to the development of systolic hypertension and to a substantial increase in pulse pressure. An augmented pulse pressure can be a predictor of the development of hypertension, wh ...

Oxford University Press2008

A new implantable device for telemetric control of pulmonary blood flow

Nikolaos Stergiopoulos

The main problem encountered in pulmonary artery banding is the difficulty in determining the optimal perimeter of the band, and sometime repeated surgical operations are required to adjust the band perimeter in order to control the pulmonary blood flow. T ...

2007

Arterial remodeling in response to hypertension using a constituent-based model

Nikolaos Stergiopoulos, Alkiviadis Tsamis

Hypertension-induced arterial remodeling has been previously modeled using stress-driven remodeling rate equations in terms of global geometrical adaptation (Rachev A, Stergiopulos N, Meister JJ. Theoretical study of dynamics of arterial wall remodeling in ...

2007

SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development

Michel Aguet

Spatial-temporal regulation of bone morphogenetic protein (BMP) and Wnt activity is essential for normal cardiovascular development, and altered activity of these growth factors causes maldevelopment of the cardiac outflow tract and great arteries. In the ...

Wiley-Blackwell2007

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