Publications related to Primary biliary cholangitis

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

Henning Paul-Julius Stahlberg, Dongchun Ni

BSEP (ABCB11) is an ATP-binding cassette transporter that is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. BSEP dysfunction, caused by mutations or induced by drugs, is frequently associated with severe cholestatic live ...

Berlin2023

Hysteretic behaviour of welded connections with highly inelastic panel zones

Dimitrios Lignos, Andronikos Skiadopoulos

The current practice in capacity-designed steel moment resisting frames (MRFs) worldwide allows for limitedshear yielding in the column web panel zone. As such, inelastic deformations concentrate near the beam ends, thereby leading to flexural stre ...

Ernst & Sohn2023

Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

Cristina Ramona Cudalbu, Jocelin Grosse, Veronika Rackayová, Emmanuelle Ines Flatt

Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora ...

2021

Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease

Cristina Ramona Cudalbu, Veronika Rackayová

Type C hepatic encephalopathy (type C HE) is increasingly suspected in children with chronic liver disease (CLD), and believed to underlie long-term neurocognitive difficulties. The molecular underpinnings of type C HE in both adults and children are incom ...

2020

Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis

Kristina Schoonjans, Jian Liu, Bhoomika Mathur

Background & Aims: Liver diseases are caused by many factors, such as genetics, nutrition, and viruses. Therefore, it is important to delineate transcriptomic changes that occur in various liver diseases. Methods: We performed high-throughput sequencing of ...

2020

In vivo detection of gamma-glutamyl-transferase up-regulation in glioma using hyperpolarized gamma-glutamyl-[1-C-13]glycine

Hikari Ananda Infinity Yoshihara

Glutathione (GSH) is often upregulated in cancer, where it serves to mitigate oxidative stress. gamma-glutamyl-transferase (GGT) is a key enzyme in GSH homeostasis, and compared to normal brain its expression is elevated in tumors, including in primary gli ...

NATURE PUBLISHING GROUP2020

Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage

Vassily Hatzimanikatis, Vikash Kumar Pandey, Anush Chiappino-Pepe, Dominique Soldati-Favre

Plasmodium gene functions in mosquito and liver stages remain poorly characterized due to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed more than 1,300 barcoded P. berghei mutants through the life cycle. We dis ...

CELL PRESS2019

Investigating the deregulation of metabolic tasks via Minimum Network Enrichment Analysis (MiNEA) as applied to nonalcoholic fatty liver disease using mouse and human omics data

Vassily Hatzimanikatis, Vikash Kumar Pandey

Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndromes spanning a wide spectrum of diseases, from simple steatosis to the more complex nonalcoholic steatohepatitis. To identify the deregulation that occurs in metabolic processes at ...

2019

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Primary biliary cholangitis

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

Hysteretic behaviour of welded connections with highly inelastic panel zones

Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression

Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease

Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis

In vivo detection of gamma-glutamyl-transferase up-regulation in glioma using hyperpolarized gamma-glutamyl-[1-C-13]glycine

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver

Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage

Investigating the deregulation of metabolic tasks via Minimum Network Enrichment Analysis (MiNEA) as applied to nonalcoholic fatty liver disease using mouse and human omics data

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Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression

Investigating the deregulation of metabolic tasks via Minimum Network Enrichment Analysis (MiNEA) as applied to nonalcoholic fatty liver disease using mouse and human omics data

Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

Hysteretic behaviour of welded connections with highly inelastic panel zones

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver

Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage

Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease

Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis

In vivo detection of gamma-glutamyl-transferase up-regulation in glioma using hyperpolarized gamma-glutamyl-[1-C-13]glycine