Concept

Primary biliary cholangitis

Related publications (39)

Superior sensing performance of multi-walled carbon nanotube-based electrodes to detect unconjugated bilirubin

Giovanni De Micheli, Sandro Carrara, Irene Taurino

The direct electrochemical behaviour of bilirubin in the physio-pathological concentration range and at physio- logical pH was investigated by cyclic voltammetry. Nanostructured electrodes with a thin film of multi-walled carbon nanotubes exhibited a highe ...

Elsevier2013

Effect of loading rate on fracture toughness and failure micromechanisms in marble

Jian Zhao, Qianbing Zhang

Fracture experiments in a notched semi-circular bend configuration were conducted to characterize rate effects and failure micromechanisms of a marble using a servo-hydraulic machine and a modified split Hopkinson pressure bar. Three real-time measurement ...

Elsevier2013

CSP--a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytes

One target of protective immunity against the Plasmodium liver stage in BALB/c mice is represented by the circumsporozoite protein (CSP), and mainly involves its recognition by IFN-γ producing specific CD8+T-cells. In a previous in vitro study we showed th ...

Public Library of Science2012

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output

Kristina Schoonjans

Chronic cholangiopathies have limited therapeutic options and represent an important indication for liver transplantation. The nuclear farnesoid X receptor (FXR) and the membrane G protein-coupled receptor, TGR5, regulate bile acid (BA) homeostasis and inf ...

2011

Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets

David Michael Suter

Hepatitis C virus (HCV) perturbs the host's lipid metabolism and often results in hepatic steatosis. In nonalcoholic fatty liver disease, the intrahepatic down-regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a critical mecha ...

2011

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

Johan Auwerx, Kristina Schoonjans, Chikage Mataki

We evaluated the metabolic impact of farnesoid X receptor (FXR) activation by administering a synthetic FXR agonist (GW4064) to mice in which obesity was induced by a high fat diet. Administration of GW4064 accentuated body weight gain and glucose intolera ...

2011

Sigma Factor F does not Prevent Rifampin Inhibition of RNA Polymerase or Cause Rifampin Tolerance in Mycobacterium tuberculosis

Stewart Cole, Florence Pojer, Claudia Sala, Ruben Hartkoorn, Jeffrey Chen, Sophie Magnet

The tolerance of Mycobacterium tuberculosis to anti-tuberculosis drugs is a major reason for the lengthy therapy needed to treat a tuberculosis infection. Rifampin is a potent inhibitor of RNA polymerase (RNAP) in vivo, but has been shown to be less effect ...

2010

Differentiation of human embryonic stem cells to hepatocytes

Noam Beckmann

Many liver diseases involve hepatocyte malfunction. In most cases, transplantation of corrected hepatocytes would correct for disease symptoms. Liver donor shortage and hepatocyte inability to proliferate in vitro accentuate this problem. Embryonic stem an ...

2010

Aggravation of viral hepatitis by platelet-derived serotonin

Nicola Harris

More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in li ...

2008

In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue

Johan Auwerx

We generated and characterized a firefly luciferase reporter mouse for the nuclear receptor farnesoid X receptor (FXR). This FXR reporter mouse has basal luciferase expression in the terminal ileum, an organ with well-characterized FXRalpha signaling. In v ...

2007

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