Concept
Cyclic adenosine monophosphate
Related publications (92)
Structure-function analysis of the cyclic β-1,2-glucan synthase from Agrobacterium tumefaciens
Henning Paul-Julius Stahlberg, Dongchun Ni
The synthesis of complex sugars is a key aspect of microbial biology. Cyclic beta-1,2-glucan (C beta G) is a circular polysaccharide critical for host interactions of many bacteria, including major pathogens of humans (Brucella) and plants (Agrobacterium). ...
Nature Portfolio2024SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells
Loïc Dayon, Andreas Wiederkehr
Glucose sensing in pancreatic D-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteo-mics to search for downstream effectors of glucose-dependent signal tran ...
COMPANY BIOLOGISTS LTD2023Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting
Lijing Xin, Daniel Wenz, Mark Stephan Widmaier, Songi Lim
A new and efficient magnetisation transfer P-31 magnetic resonance fingerprinting (MT-P-31-MRF) approach is introduced to measure the creatine kinase metabolic rate kCK between phosphocreatine (PCr) and adenosine triphosphate (ATP) i ...
WILEY2023Metabolic regulation of cytokinesis in Schizosaccharomyces pombe
All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...
EPFL2022Primary data for EPFL thesis "Metabolic regulation of cytokinesis in Schizosaccharomyces pombe"
All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...
EPFL Infoscience2022AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets
AMP-activated Protein Kinase (AMPK) is a central regulator of energy homeostasis and a promising drug target for metabolic disorders. It exists as complexes of three subunits, a catalytic alpha, and two regulatory beta and gamma subunits. The regulation of ...
EPFL2022Gαi1 inhibition mechanism of ATP-bound adenylyl cyclase type 5
Ursula Röthlisberger, Siri Camee van Keulen, Daniele Narzi
Conversion of adenosine triphosphate (ATP) to the second messenger cyclic adenosine monophosphate (cAMP) is an essential reaction mechanism that takes place in eukaryotes, triggering a variety of signal transduction pathways. ATP conversion is catalyzed by ...
2021PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle
Johan Auwerx, Hao Li, Daniel Garcia
Rapid alterations in cellular metabolism allow tissues to maintain homeostasis during changes in energy availability. The central metabolic regulator acetyl-CoA carboxylase 2 (ACC2) is robustly phosphorylated during cellular energy stress by AMP-activated ...
CELL PRESS2020BAF restricts cGAS on nuclear DNA to prevent innate immune activation
Mahmut Selman Sakar, Beat Fierz, Andrea Ablasser, Baptiste Claude André Guey, Alexiane Clara Decout, Murat Kaynak, Kristina Makasheva, Marilena Wischnewski
The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard a ...
2020Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates
Kei Sakamoto, Maria Deak, Caterina Collodet, Susanne Seitz
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis, acting as a sensor of energy and nutrient status. As such, AMPK is considered a promising drug target for treatment of medical conditions particularly associated with me ...
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