Publications related to Cyclic adenosine monophosphate

Structure-function analysis of the cyclic β-1,2-glucan synthase from Agrobacterium tumefaciens

Henning Paul-Julius Stahlberg, Dongchun Ni

The synthesis of complex sugars is a key aspect of microbial biology. Cyclic beta-1,2-glucan (C beta G) is a circular polysaccharide critical for host interactions of many bacteria, including major pathogens of humans (Brucella) and plants (Agrobacterium). ...

Nature Portfolio2024

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Loïc Dayon, Andreas Wiederkehr

Glucose sensing in pancreatic D-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteo-mics to search for downstream effectors of glucose-dependent signal tran ...

COMPANY BIOLOGISTS LTD2023

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

Lijing Xin, Daniel Wenz, Mark Stephan Widmaier, Songi Lim

A new and efficient magnetisation transfer P-31 magnetic resonance fingerprinting (MT-P-31-MRF) approach is introduced to measure the creatine kinase metabolic rate kCK

{k}_{\mathrm{CK}}

between phosphocreatine (PCr) and adenosine triphosphate (ATP) i ...

WILEY2023

Metabolic regulation of cytokinesis in Schizosaccharomyces pombe

Özge Uysal Özdemir

All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...

EPFL2022

Primary data for EPFL thesis "Metabolic regulation of cytokinesis in Schizosaccharomyces pombe"

Özge Uysal Özdemir

All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...

EPFL Infoscience2022

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets

Katyayanee Neopane

AMP-activated Protein Kinase (AMPK) is a central regulator of energy homeostasis and a promising drug target for metabolic disorders. It exists as complexes of three subunits, a catalytic alpha, and two regulatory beta and gamma subunits. The regulation of ...

EPFL2022

Gαi1 inhibition mechanism of ATP-bound adenylyl cyclase type 5

Ursula Röthlisberger, Siri Camee van Keulen, Daniele Narzi

Conversion of adenosine triphosphate (ATP) to the second messenger cyclic adenosine monophosphate (cAMP) is an essential reaction mechanism that takes place in eukaryotes, triggering a variety of signal transduction pathways. ATP conversion is catalyzed by ...

2021

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

Johan Auwerx, Hao Li, Daniel Garcia

Rapid alterations in cellular metabolism allow tissues to maintain homeostasis during changes in energy availability. The central metabolic regulator acetyl-CoA carboxylase 2 (ACC2) is robustly phosphorylated during cellular energy stress by AMP-activated ...

CELL PRESS2020

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Mahmut Selman Sakar, Beat Fierz, Andrea Ablasser, Baptiste Claude André Guey, Alexiane Clara Decout, Murat Kaynak, Kristina Makasheva, Marilena Wischnewski

The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard a ...

2020

Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates

Kei Sakamoto, Maria Deak, Caterina Collodet, Susanne Seitz

AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis, acting as a sensor of energy and nutrient status. As such, AMPK is considered a promising drug target for treatment of medical conditions particularly associated with me ...

ELSEVIER SCIENCE INC2019

Cyclic adenosine monophosphate

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Structure-function analysis of the cyclic β-1,2-glucan synthase from Agrobacterium tumefaciens

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

Metabolic regulation of cytokinesis in Schizosaccharomyces pombe

Primary data for EPFL thesis "Metabolic regulation of cytokinesis in Schizosaccharomyces pombe"

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets

Gαi1 inhibition mechanism of ATP-bound adenylyl cyclase type 5

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates

Structure-function analysis of the cyclic β-1,2-glucan synthase from Agrobacterium tumefaciens

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Gαi1 inhibition mechanism of ATP-bound adenylyl cyclase type 5

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

Metabolic regulation of cytokinesis in Schizosaccharomyces pombe

Primary data for EPFL thesis "Metabolic regulation of cytokinesis in Schizosaccharomyces pombe"

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates