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Multiscale modeling of lymphatic drainage from tissues using homogenization theory

Lymphatic capillary drainage of interstitial fluid under both steady-state and inflammatory conditions is important for tissue fluid balance, cancer metastasis, and immunity. Lymphatic drainage function is critically coupled to the fluid mechanical propert ...

Elsevier2011

Leukocyte-endothelial cell interaction is necessary for photodynamic therapy induced vascular permeabilization

Hubert van den Bergh, Elodie Debefve, Hans-Anton Lehr

Photodynamic therapy (PDT) affects vascular barrier function and thus increases vessel permeability. This phenomenon may be exploited to facilitate targeted drug delivery and may lead to a new clinical application of photodynamic therapy. Here, we investig ...

2011

Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema

Melody Swartz, Joseph Rutkowski

Primary lymphedema is a congenital pathology of dysfunctional lymphatic drainage characterized by swelling of the limbs, thickening of the dermis, and fluid and lipid accumulation in the underlying tissue. Two mouse models of primary lymphedema, the Chy mo ...

American Society for Investigative Pathology2010

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium

Melody Swartz, Witold Waldemar Kilarski, Joseph Rutkowski, James Brandon Dixon, Dimana Miteva

RATIONALE: Lymphatic transport of peripheral interstitial fluid and dendritic cells (DCs) is important for both adaptive immunity and maintenance of tolerance to self-antigens. Lymphatic drainage can change rapidly and dramatically on tissue injury or infl ...

American Heart Association2010

Analysis of the swelling pressure development in opalinus clay – experimental and modelling aspects

Lyesse Laloui, Hervé Péron, Mathieu Nuth, Simon Salager

In the context of nuclear waste geological storage, deep argillaceous formations are likely to be subjected to complex mechanical, hydraulic, and thermal loads. In particular, the argillaceous material can be firstly dried, and then re-wetted. During the l ...

European Association of Geoscientists & Engineers (EAGE)2009

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

Melody Swartz, Joseph Rutkowski, Sai Reddy

Lymphatic vessels are essential for lipid absorption and transport. Despite increasing numbers of observations linking lymphatic vessels and lipids, little research has been devoted to address how dysregulation of lipid balance in the blood, ie, dyslipidem ...

American Society for Investigative Pathology2009

Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in vitro characterization and in vivo animal imaging studies

Lothar Helm

The recently reported amphiphilic chelate,

[Gd(EPTPAC_{16})(H_2O)]^{2-}

, forms supramolecular aggregates in aqueous solution by self-assembly of the monomers with a relaxometrically determined critical micellar concentration (CMC) of 0.34 mM. The effect ...

2008

Design and Optimization of a Lactate Amperometric Biosensor based on Lactate Oxidase and Multi Walled-Carbon Nanotubes

Giovanni De Micheli, Sandro Carrara, Cristina Boero

Lactate concentration in physiological fluids is an indicator of the energy production under anaerobic conditions of the whole organism [1]. Normal value for lactate level in blood ranges from 0.5 – 2.5 mM. Blood lactate values exceeding 7-8 mM are sometim ...

2008

Interfacial interactions and colloid retention under steady flows in a capillary channel

Dani Or, Yan Jin

Colloidal interfacial interactions in a capillary channel under different chemical and flow conditions were studied using confocal microscopy. Fluorescent latex microspheres (1.1 mu m) were employed as model colloids and the effects of ionic strength and f ...

Elsevier2006

Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9

Melody Swartz, Joseph Rutkowski

Disturbances in the microcirculation can lead to secondary lymphedema, a common pathological condition that, despite its frequency, still lacks a cure. Lymphedema is clinically well described, but while the genetic underpinnings that cause lymphatic malfor ...

2006

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Multiscale modeling of lymphatic drainage from tissues using homogenization theory

Leukocyte-endothelial cell interaction is necessary for photodynamic therapy induced vascular permeabilization

Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium

Analysis of the swelling pressure development in opalinus clay – experimental and modelling aspects

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in vitro characterization and in vivo animal imaging studies

Design and Optimization of a Lactate Amperometric Biosensor based on Lactate Oxidase and Multi Walled-Carbon Nanotubes

Interfacial interactions and colloid retention under steady flows in a capillary channel

Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9

Multiscale modeling of lymphatic drainage from tissues using homogenization theory

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

Design and Optimization of a Lactate Amperometric Biosensor based on Lactate Oxidase and Multi Walled-Carbon Nanotubes

Analysis of the swelling pressure development in opalinus clay – experimental and modelling aspects

Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema

Leukocyte-endothelial cell interaction is necessary for photodynamic therapy induced vascular permeabilization

Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in vitro characterization and in vivo animal imaging studies

Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9

Interfacial interactions and colloid retention under steady flows in a capillary channel