Concept

Myoepithelial cell

Related publications (35)

Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis

Worldwide, breast cancer incidence has been increasing for decades. Exposure to reproductive hormones, as occurs with recurrent menstrual cycles, affects breast cancer risk, and can promote disease progression. Exogenous hormones and endocrine disruptors h ...

2015

ER and PR signaling nodes during mammary gland development

Cathrin Brisken, Tamara Tanos, Lucia Jimenez Rojo

The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and are implicated in breast cancer. Most of our understanding of the molecular mechanisms of estrogen receptor (ER) and progesterone receptor (PR) signaling ste ...

BioMed Central2012

Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis

Oliver Hantschel

A fundamental aspect of epithelial homeostasis is the dependence on specific growth factors for cell survival, yet the underlying mechanisms remain obscure. We found an "inverse" mode of receptor tyrosine kinase signaling that directly links ErbB receptor ...

2012

Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells

Léa Chanson

Loss of organization is a principle feature of cancers; therefore it is important to understand how normal adult multilineage tissues, such as bilayered secretory epithelia, establish and maintain their architectures. The self-organization process that dri ...

2011

ID4 regulates mammary gland development by suppressing p38MAPK activity

Yiming Li, Cathrin Brisken, Marian Caikovski, Xiuwei Zhang, Jun Dong

The ID family of helix-loop-helix proteins regulates cell proliferation and differentiation in many different developmental pathways, but the functions of ID4 in mammary development are unknown. We report that mouse Id4 is expressed in cap cells, basal cel ...

2011

Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland

Cathrin Brisken, Ayyakkannu Ayyanan, Marian Caikovski

The mouse mammary gland develops postnatally under the control of female reproductive hormones. Estrogens and progesterone trigger morphogenesis by poorly understood mechanisms acting on a subset of mammary epithelial cells (MECs) that express their cognat ...

National Academy of Sciences2010

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

Cathrin Brisken, Maryse Fiche

The breast epithelium has two major compartments, luminal and basal cells, that are established and maintained by poorly understood mechanisms. The p53 homolog, p63, is required for the formation of mammary buds, but its function in the breast after birth ...

Nature Publishing Group2010

Role of canonical Wnt signaling in mammary gland development

Renuga Devi Rajaram

The female reproductive hormones estrogens, progesterone, and prolactin control postnatal breast development and are important to breast carcinogenesis. In particular, exposure to progesterone is tightly linked to breast cancer risk. Using the mouse as a m ...

EPFL2010

Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics

Cathrin Brisken, Lucia Jimenez Rojo

Amphiregulin (AREG), a ligand for epidermal growth factor receptor, is required for mammary gland ductal morphogenesis and mediates estrogen actions in vivo, emerging as an essential growth factor during mammary gland growth and differentiation. The COMMA- ...

Elsevier2010

Hormone Action in the Mammary Gland

Cathrin Brisken

A woman's breast cancer risk is affected by her reproductive history. The hormonal milieu also influences the course of the disease. The female reproductive hormones, estrogens, progesterone, and prolactin, have a major impact on breast cancer and control ...

2010

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