Publications related to Cytomegalovirus

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity

Author summary Human cytomegalovirus (HCMV) infection is the foremost viral cause of congenital birth defects. Attempts to vaccinate against HCMV brought moderate, though not sufficient, reduction in infection. Moreover, phase II clinical trial with gB for ...

PUBLIC LIBRARY SCIENCE2020

Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspective

Kristen Kay Irwin, Jeffrey David Jensen, Susanne Petra Pfeifer, Cornelia Pokalyuk

Given the strong selective pressures often faced by populations when colonizing a novel habitat, the level of variation present on which selection may act is an important indicator of adaptive potential. While often discussed in an ecological context, this ...

Wiley2017

On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations

Jeffrey David Jensen, Sebastian Matuszewski, Susanne Petra Pfeifer

Intrahost and interhost assessments of viral diversity are often treated as measures of separate and distinct evolutionary processes, with numerous investigations reporting seemingly incompatible results between the two. For example, in human cytomegalovir ...

Amer Soc Microbiology2017

Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

Didier Trono, Isabelle Barde, Adamantia Kapopoulou, Marco Cassano, Suk Min Jang, Benjamin Rauwel

Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long infections notably through the establishment of latency in hematopoietic stem cells (HSC). Bouts of reactivation are normally controlled by the immune system, but can be fat ...

2015

Limits and patterns of cytomegalovirus genomic diversity in humans

Jeffrey David Jensen, Cornelia Pokalyuk

Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural infection although little is known about the limits or patterns of HCMV diversity among humans. To address this deficiency, we analyzed genomic diversity among congeni ...

Natl Acad Sciences2015

Human cytomegalovirus intrahost evolution - a new avenue for understanding and controlling herpesvirus infections

Jeffrey David Jensen

Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on t ...

Elsevier Sci Ltd2014

Host miRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency

Jiri Vanicek

Reactivation of human cytomegalovirus (HCMV) is a significant cause of disease and death in immunocompromised patients underscoring the need to understand how latency is controlled. Here we demonstrate that HCMV has evolved to utilize cellular miRNAs in ce ...

American Society for Microbiology2014

Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection

Jeffrey David Jensen

Populations of human cytomegalovirus (HCMV), a large DNA virus, are highly polymorphic in patient samples, which may allow for rapid evolution within human hosts. To understand HCMV evolution, longitudinally sampled genomic populations from the urine and p ...

Public Library of Science2013

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Cytomegalovirus

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity

Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspective

On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations

On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity

Methods for purging isolated organs and cells from latent human cytomegalovirus

Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

Limits and patterns of cytomegalovirus genomic diversity in humans

Human cytomegalovirus intrahost evolution - a new avenue for understanding and controlling herpesvirus infections

Host miRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency

Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection

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Chat with Graph Search

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity

Human cytomegalovirus intrahost evolution - a new avenue for understanding and controlling herpesvirus infections

Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspective

On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations

On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity

Host miRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency

Methods for purging isolated organs and cells from latent human cytomegalovirus

Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

Limits and patterns of cytomegalovirus genomic diversity in humans

Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection