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Bacterial cells behave as individuals despite being genetically identical and subject to the same environment. Although the underlying mechanisms of cellular individuality are not well understood, temporal variation of gene expression and protein levels in ...
We have developed a method to analyze in detail, translocation events providing a novel and flexible tool for data analysis of nanopore experiments. Our program, called OpenNanopore, is based on the cumulative sums algorithm (CUSUM algorithm). This algorit ...
The conventional CAD/CAM approach to design does not show the essential spatial relationships between user and product that are crucial for intuitive design analysis. As populations age and the home appliance market stagnates, Universal Design principles i ...
Alzheimer's disease (AD) is a devastating disease affecting predominantly the aging population. One of the characteristic pathological hallmarks of AD are neuritic plaques, consisting of amyloid-beta peptide (A beta). While there has been some advancement ...
Anti-coagulation treatments are required for medical conditions that become more and more frequent with the ageing of the population in developed countries (atrial fibrillation, deep-venous thrombosis, heart prosthetic valves, etc.). These treatments gener ...
Muscle weakness is a common symptom in elderly population and in children with Duchenne muscular dystrophy (DMD), causing impaired mobility. DMD is a devastating degenerative disease caused by a mutation in the dystrophin gene, leading to the absence of th ...
We conduct an experiment where ten attendees of an open-air music festival are acting as Bluetooth probes. We then construct a parametric statistical model to estimate the total number of visible Bluetooth devices in the festival area. By comparing our est ...
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Sequences of events in noise-driven excitable systems with slow variables often show serial correlations among their intervals of events. Here, we employ a master equation for generalized non-renewal processes to calculate the interval and count statistics ...
Unique worldwide, Lake Kivu stores enormous amounts of CH4 and CO2. A recent study reported that CH4 concentrations in the lake have increased by up to 15% in the last 30 years and that accumulation at this rate could lead to catastrophic outgassing by sim ...
Using the transient interleukin (IL)-2 secretion of effector T helper (Teff) cells as an example, we show that self-organizing multicellular behavior can be modeled and predicted by an adaptive gene network model. Incorporating an adaptation algorithm we e ...