Concept

Primary metabolite

Related publications (36)

New optical tools for non-invasive imaging and quantification of glucose and nicotinamide riboside in living cells and animals

Glucose is one of the most important metabolites that plays a key role in living organisms, as it is the primary energy source. Glucose metabolism is also an integral part in the pathogenesis of diabetes and cancer. Despite this tremendous impact of glucos ...

EPFL2016

Protein acetylation in metabolism-metabolites and cofactors

Johan Auwerx, Elena Katsyuba, Hongbo Zhang, Keir Joe Menzies

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility. Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolis ...

2015

Multiscattering-enhanced optical probes for biosensing

Volodymyr Koman

Although reactive oxygen species (ROS) are an inescapable part of every living organism, we are only beginning to understand their functions and mechanics. As of now, we know that ROS are involved in cell signalling, stress-response and defence against pat ...

EPFL2015

LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters

Kristin Schirmer

A targeted analytical method was established to determine a large number of chemicals known to interfere with the gluco- and mineralocorticoid signalling pathway. The analytes comprise 30 glucocorticoids and 9 mineralocorticoids. Ten out of these corticost ...

Springer Heidelberg2014

Are glutamate and lactate increases ubiquitous to physiological activation? A 1H functional MR spectroscopy study during motor activation in human brain at 7Tesla

Rolf Gruetter, Lijing Xin, Benoît Schaller

Recent studies at high field (7 Tesla) have reported small metabolite changes, in particular lactate and glutamate (below 0.3 μmol/g) during visual stimulation. These studies have been limited to the visual cortex because of its high energy metabolism and ...

Elsevier2014

Thermodynamics-based Significance Ranking of Candidates for Metabolomics

Vassily Hatzimanikatis

Integration of experimental measurements of intracellular metabolite concentrations in genome scale models restricts the thermodynamically feasible flux space and reduces uncertainty regarding the net outcome of by-directional reactions. By combining tFBA, ...

2013

Thermodynamics-Based Significance Ranking of Candidates for Metabolomics

Vassily Hatzimanikatis

Cellular metabolism is the driving force of all living cells and organisms. Numerous research projects undertaken over the past century have attempted to decipher the function and operating principles of metabolism with varying degrees of success. A wide s ...

2013

Characterization of sustained BOLD activation in the rat barrel cortex and Neurochemical consequences

Rolf Gruetter, Lijing Xin, Nathalie Just, Hanne Frenkel

To date, only a couple of functional MR spectroscopy (fMRS) studies were conducted in rats. Due to the low temporal resolution of 1H-MRS techniques, prolonged stimulation paradigms are necessary for investigating the metabolic outcome in the rat brain duri ...

Elsevier2013

Pharmaceuticals and their human metabolites in Lake Geneva: occurrence, fate and ecotoxicological relevance

Tamar Kohn, Florence Bonvin, Rebecca Rutler

This study assesses the presence, fate and effects of five environmentally relevant pharmaceuticals and eight of their corresponding human metabolites in Lake Geneva. Over a 10-month period, lake samples were taken at various depths and locations in the Vi ...

2012

A novel approach to find the missing links in genome-scale metabolic models: The BridgeIt mrthod

Vassily Hatzimanikatis, Keng Cher Soh, Marianne Seijo

Genome-scale metabolic reconstructions (GSMRs) are valuable resources in the analysis and understanding of cellular metabolism. They are based on genome sequence and annotation, and they are to develop bottom-up mathematical models of metabolic networks. T ...

2012

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