Concept
Chronic traumatic encephalopathy
Related publications (41)
Safety, tolerability and blinding efficiency of non-invasive deep transcranial temporal interference stimulation: first experience from more than 250 sessions
Friedhelm Christoph Hummel, Pierre Theopistos Vassiliadis, Elena Beanato, Fabienne Windel, Emma Marie D Stiennon, Maximilian Jonas Wessel
Objective. Selective neuromodulation of deep brain regions has for a long time only been possible through invasive approaches, because of the steep depth-focality trade-off of conventional non-invasive brain stimulation (NIBS) techniques. Approach. An appr ...
Bristol2024Cortical and subcortical changes in resting-state neuronal activity and connectivity in early symptomatic ALS and advanced frontotemporal dementia
The objective of this study was to examine if patterns of resting-state brain activity and functional connectivity in cortical and subcortical regions in patients with early symptomatic amyotrophic lateral sclerosis (ALS) resemble those of behavioural vari ...
ELSEVIER SCI LTD2022Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates
Grégoire Courtine, Tomislav Milekovic, Flavio Raschella
Progressive supranuclear palsy is a primary tauopathy affecting both neurons and glia and is responsible for both motor and cognitive symptoms. Recently, it has been suggested that progressive supranuclear palsy tauopathy may spread in the brain from cell ...
OXFORD UNIV PRESS2022Cerebral Metabolic Dysfunction at the Acute Phase of Traumatic Brain Injury Correlates with Long-Term Tissue Loss
Adriano Bernini, Ricardo Alberto Corredor Jerez, Neil Graham
Following traumatic brain injury (TBI), cerebral metabolic dysfunction, characterized by an elevated cerebral microdialysis (CMD) lactate/pyruvate (LP) ratio, is associated with poor outcome. However, the exact pathophysiological mechanisms underlying this ...
MARY ANN LIEBERT, INC2022Trans‐seeding of Alzheimer‐related tau protein by a yeast prion
Henning Paul-Julius Stahlberg, Zhiva Skachokova
Abnormal tau protein aggregates constitute a hallmark of Alzheimer's disease. The mechanisms underlying the initiation of tau aggregation in sporadic neurodegeneration remain unclear. Here we investigate whether a non-human prion can seed tau aggregation. ...
2022C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy
Encephalopathy is a neurological complication of COVID-19. The objective of this exploratory study is to investigate the link between systemic inflammation and brain microstructural changes (measured by diffusion-weighted imaging) in patients with COVID-19 ...
SPRINGER WIEN2021Label-Efficient Volumetric Deep Semantic Segmentation of Intracranial Hemorrhages
Traumatic brain injuries is one of the major cause of death and disability worldwide especially among young people. The initial injury can later develop into a secondary injury that is particularly lethal. The patient’s survival relies on fast and proper a ...
2021New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases
Jian Wang, Friedhelm Christoph Hummel
The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially p ...
2021Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies
The compound screening was initiated with a direct staining assay to identify compounds binding to Tau aggregates and not Abeta plaques using human brain sections derived from late stage Alzheimer's disease donors. The binding of Tau aggregate selective co ...
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER2020Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology
Bernard Schneider, Philippe Colin, Vanessa Laversenne
The brain pathology of Alzheimer’s disease (AD) is characterized by the misfolding and aggregation of both the amyloid beta (Aβ) peptide and hyperphosphorylated forms of the tau protein. Initial Aβ deposition is considered to trigger a sequence of deleteri ...
2020