Concept

Artemisia annua

Related publications (7)

Clinical relevance of low-densityPlasmodium falciparumparasitemia in untreated febrile children: A cohort study

Background Low-density (LD)Plasmodiuminfections are missed by standard malaria rapid diagnostic tests (standard mRDT) when the blood antigen concentration is below the detection threshold. The clinical impact of these LD infections is unknown. This study i ...

2020

Identifying and targeting key cellular mechanisms for proliferation in Plasmodium parasites: a combined experimental and computational strategy

Vassily Hatzimanikatis

Recent advances in cell genome editing techniques enable the generation of high-throughput gene knockout data in the malaria parasites in vivo. Integrative analysis of this data can lead to the identification of biological mechanisms that explain the obser ...

2017

Identifying and targeting key cellular mechanisms for proliferation in Plasmodium parasites: a combined experimental and computational strategy

Vassily Hatzimanikatis

2017

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Luc Patiny, Anna Lee, Eileen Ryan

The development of new antimalarial compounds remains a pivotal part of the strategy for malaria elimination. Recent large-scale phenotypic screens have provided a wealth of potential starting points for hit-to-lead campaigns. One such public set is explor ...

Amer Chemical Soc2016

Expression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor Classes

Serena Pulcini

Background. The mechanism of action of artemisinins against malaria is unclear, despite their widespread use in combination therapies and the emergence of resistance. Results. Here, we report expression of PfATP6 (a SERCA pump) in yeast and demonstrate its ...

Oxford University Press2013

XAFS studies of the synthetic substitutes of hemozoin

Andrzej Sienkiewicz

The local atomic structure around iron atoms of two synthetic analogues of malarial pigment product is characterized by iron K-edge X-ray absorption fine structure spectroscopy (XAFS). Malarial pigment, also termed hemozoin, is a condensed phase of ferripr ...

2010

Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.

As part of our search for new antimalarial drugs, we have screened for inhibitors of Pfnek-1, a protein kinase of Plasmodium falciparum, in south Pacific marine sponges. On the basis of a preliminary screening, the ethanolic crude extract of a new species ...

Elsevier2006

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