Concept
Myogenin
Related publications (8)
Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle
Martinus Gijs, Raphaël Etienne Jean Trouillon, Martin Rainer Wohlwend
Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear. Here, we used fixed and live-cell imaging to study microtubule-based ...
eLIFE SCIENCES PUBL LTD2023Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia
Johan Auwerx, Davide D'Amico, Qi Wang, Sébastien Robert Victor Herzig, Maroun Bou Sleiman, Martin Rainer Wohlwend, Peiling Luan, Pirkka-Pekka Untamo Laurila, Barbara Moreira Crisol
Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic a ...
SPRINGERNATURE2022Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism
Vera Monica Lemos Da Silva, Ludger Jan Elzuë Goeminne, Barbara Moreira Crisol, Eduardo Rochete Ropelle
Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated that IL6 activates the ERK1/2 pathway in the ventromedial hypothalamus (VMH), stimulating AMPK/ACC signaling and fatty acid oxidation in mouse skeletal muscle. Bioinfo ...
2022Tbx6, Mesp-b and ripply1 regulate the onset of skeletal myogenesis in zebrafish
During embryonic development, the paraxial mesoderm becomes segmented into somites, within which proliferative muscle progenitors and muscle fibers establish the skeletal musculature. Here, we demonstrate that a gene network previously implicated in somite ...
2015A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation
Didier Trono, Evaristo Jose Planet Letschert, Marco Cassano, Suk Min Jang
The transcriptional activator MyoD serves as a master controller of myogenesis. Often in partnership with Mef2 (myocyte enhancer factor 2), MyoD binds to the promoters of hundreds of muscle genes in proliferating myoblasts yet activates these targets only ...
Cold Spring Harbor Lab Press, Publications Dept2015Essential role of Gab1 for signaling by the c-Met receptor in vivo
The docking protein Gab1 binds phosphorylated c-Met receptor tyrosine kinase directly and mediates signals of c-Met in cell culture. Gab1 is phosphorylated by c-Met and by other receptor and nonreceptor tyrosine kinases. Here, we report the functional anal ...
2000