Concept

Hypogonadism

Related publications (12)

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Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

Andrea Agnoletto

Steroid hormone receptors (HRs) are ligand-activated transcription factors that play a pivotal role in breast development and carcinogenesis. It is well established that estrogen receptor (ER) signaling is a major proliferative driver in estrogen receptor ...

EPFL2024

Androgen-deprivation therapy is the standard treatment for prostate cancer. Despite the initial response, a fraction of cases manifest progression to castration-resistant prostate cancer. PCa recurrence is possibly due to androgen-independent cancer stem c ...

AMER ASSOC CANCER RESEARCH2018

Effect-based tools for monitoring estrogenic mixtures: Evaluation of five in vitro bioassays

In vitro estrogen receptor transactivation assays (ERTAs) are increasingly used to measure the overall estrogenic activity of environmental water samples, which may serve as an indicator of exposure of fish or other aquatic organisms to (xeno)estrogens. An ...

Pergamon-Elsevier Science Ltd2017

Bile acid-FXR alpha pathways regulate male sexual maturation in mice

Kristina Schoonjans

The bile acid receptor Farnesol-X-Receptor alpha (FRX alpha) is a member of the nuclear receptor superfamily. FRX alpha is expressed in the interstitial compartment of the adult testes, which contain the Leydig cells. In adult, short term treatment (12 hou ...

Impact Journals Llc2016

Identification of the Link Between the Hypothalamo-Pituitary Axis and the Testicular Orphan Nuclear Receptor NR0B2 in Adult Male Mice

Kristina Schoonjans

The small heterodimer partner (SHP, nuclear receptor subfamily 0, group B, member 2; NR0B2) is an atypical nuclear receptor known mainly for its role in bile acid homeostasis in the enterohepatic tract. We previously showed that NR0B2 controls testicular f ...

Endocrine Soc2015

Bile Acids Alter Male Fertility Through G-Protein-Coupled Bile Acid Receptor 1 Signaling Pathways in Mice

Kristina Schoonjans

Bile acids (BAs) are signaling molecules that are involved in many physiological functions, such as glucose and energy metabolism. These effects are mediated through activation of the nuclear and membrane receptors, farnesoid X receptor (FXR-alpha) and TGR ...

Wiley-Blackwell2014

LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters

Kristin Schirmer

A targeted analytical method was established to determine a large number of chemicals known to interfere with the gluco- and mineralocorticoid signalling pathway. The analytes comprise 30 glucocorticoids and 9 mineralocorticoids. Ten out of these corticost ...

Springer Heidelberg2014

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Successful mammalian reproduction depends on proper synthesis of the pituitary-derived glycoprotein hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Several transcription factors cooperate to activate cell-specific and hormone-reg ...

Public Library of Science2013

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The properties of ferroelectric materials, such as lead zirconate titanate (PZT), are heavily influenced by the interaction of defects with domain walls. These defects are either intrinsic or are induced by the addition of dopants. We study here PbTiO3 (th ...

Amer Physical Soc2013

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

Johan Auwerx, Kristina Schoonjans

Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen diethylstilbestrol (DES). Although the molecular basis f ...

American Society for Clinical Investigation2009