Isernia (iˈzɛrnja) is a town and comune in the southern Italian region of Molise, and the capital of province of Isernia. Situated on a rocky crest rising from between the Carpino and the Sordo rivers, the plan of Isernia still reflects the ancient layout of the Roman town, with a central wide street, the cardo maximus, still represented by Corso Marcelli, and side streets at right angles on both sides. The commune of Isernia includes 16 frazioni. The most densely populated is Castelromano which is positioned in a plain at the base of the La Romana mount, elevation , from Isernia. The area of Isernia was settled at least 700,000 years ago: the nearby site called Pineta has been cited in the magazine Science as the most ancient site where traces of use of fire by humans have been found. The city's Roman name, Aesernia, reflects probably a former Samnite toponym, but a connection to an Indo-European root, aeser, which means "water", is tenuous. Classical Aesernia was a city of Samnium, included within the territory of the Pentri tribe, situated in the valley of the Vulturnus (modern Volturno), on a small stream flowing into that river, and distant from Venafrum (modern Venafro). The Itinerary (in which the name is written "Serni") places it on the road from Aufidena to Bovianum, at the distance of from the former, and from the latter; but the former number is corrupt, as are the distances in the Tabula Peutingeriana. The first mention of it in history occurs in 295 BC, at which time it had already fallen into the hands of the Romans, together with the whole valley of the Vulturnus. After the complete subjugation of the Samnites, a colony, with Latin rights (colonia Latina) was settled there by the Romans in 264 BC the city, a key communication center between southern Italy and the inner Appennine Regions. This colony is again mentioned in 209 BC as one of the eighteen which remained faithful to Rome at the most trying period of the Second Punic War.