Publications related to Ear | EPFL Graph Search

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host

Anders Meibom, Jaroslaw Hubert Stolarski, Jinming Guo

Otoliths are calcium carbonate components of the stato-acoustical organ responsible for hearing and maintenance of the body balance in teleost fish. During their formation, control over, e.g., morphology and carbonate polymorph is influenced by complex ins ...

NATURE PORTFOLIO2023

Design and modelling of a compliant constant-force surgical tool for objective assessment of ossicular chain mobility

Simon Nessim Henein, Charles Baur, Loïc Benoît Tissot-Daguette

Surgeons generally assess the mobility of the ossicle chain by manual palpation using rigid elongated hooks inserted through the ear canal. As the applied forces are in the range of a few grams equivalent force, the measurement remains subjective and its r ...

IEEE2021

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Bernard Schneider, Paola Andrea Solanes Vega

Viral delivery of exogenous coding sequences into the inner ear has the potential for therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise improved strategies for viral delivery, we investigated two injection techniques, r ...

2020

Inner ear cellular imaging through scattering bone

Demetri Psaltis, Marilisa Romito

Inner ear imaging is important for the assessment of hearing disorders. A major cause of hearing loss is the damage to the sensory hair cells, which are located inside the cochlea, a spiral-shaped bone in the inner ear. Imaging of intracochear hair cells i ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Imaging hair cells through laser-ablated cochlear bone

Demetri Psaltis, Ye Pu, Marilisa Romito

We report an innovative technique for the visualization of cells through an overlying scattering medium by combining femtosecond laser bone ablation and two-photon excitation fluorescence (TPEF) microscopy. We demonstrate the technique by imaging hair cell ...

OPTICAL SOC AMER2019

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro

Hearing Loss (HL) is the most prevalent sensorineural disorder, affecting 360 million people worldwide. As genetic causes lead to 50% of pre-lingual deafness, gene therapy is considered as a potential therapeutic strategy. Mutations in the TMC1 gene are li ...

MARY ANN LIEBERT, INC2019

A 3D Microscaffold Cochlear Electrode Array for Steroid Elution

Jürgen Brugger, Joo Yeon Kim, Jongmoon Jang

In cochlear implants, the electrode insertion trauma during surgery can cause damage residual hearing. Preserving the residual hearing is an important challenge and the localized administration of drugs, such as steroids, is one of the most promising ways, ...

2019

Automated Eardrum Registration From Light-Field Data

Pascal Frossard, Ivana Tosic, Sofia Karygianni

The performance of automated classification algorithms for medical images needs to be very high and especially robust in order to be adopted into healthcare. Most of the time the main challenge is unregistered data, since it is usually captured: 1) from di ...

IEEE2018

Bulged Eardrum Detection From 3D Data

Pascal Frossard, Ivana Tosic, Sofia Karygianni

Bulging is a medical characteristic of the eardrum that is crucial for the diagnosis of acute otitis media. This work proposes a novel classification method for distinguishing bulged eardrums from non-bulged ones. The method uses novel key features extract ...

IEEE2018

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Ear

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host

Design and modelling of a compliant constant-force surgical tool for objective assessment of ossicular chain mobility

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Biomedical optical techniques for intracochlear cellular imaging

Inner ear cellular imaging through scattering bone

Imaging hair cells through laser-ablated cochlear bone

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

A 3D Microscaffold Cochlear Electrode Array for Steroid Elution

Automated Eardrum Registration From Light-Field Data

Bulged Eardrum Detection From 3D Data

Graph Chatbot

Chat with Graph Search

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Design and modelling of a compliant constant-force surgical tool for objective assessment of ossicular chain mobility

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Biomedical optical techniques for intracochlear cellular imaging

Bulged Eardrum Detection From 3D Data

Inner ear cellular imaging through scattering bone

Imaging hair cells through laser-ablated cochlear bone

Automated Eardrum Registration From Light-Field Data

A 3D Microscaffold Cochlear Electrode Array for Steroid Elution