Publications related to RNA-dependent RNA polymerase

Single Molecule Localization and Discrimination of DNA–Protein Complexes by Controlled Translocation Through Nanocapillaries

Aleksandra Radenovic, Sebastian Maerkl, Sanjin Marion, Roman Bulushev, Sebastian James Davis, Ekaterina Emilova Petrova

Through the use of optical tweezers we performed controlled translocations of DNA-protein complexes through nanocapillaries. We used RNA polymerase (RNAP) with two binding sites on a 7.2 kbp DNA fragment and a dCas9 protein tailored to have five binding si ...

American Chemical Society2016

Catalytic Metal Ions and Enzymatic Processing of DNA and RNA

Matteo Dal Peraro, Andrea Cavalli, Giulia Palermo

Two-metal-ion-dependent nucleases cleave the phosphodiester bonds of nucleic acids via the two-metal-ion (2M) mechanism. Several high-resolution X-ray structures portraying the two-metal-aided catalytic site, together with mutagenesis and kinetics studies, ...

Amer Chemical Soc2015

Noise analysis of genome-scale protein synthesis using a discrete computational model of translation

Vassily Hatzimanikatis, Julien Racle, Adam Stefaniuk

Noise in genetic networks has been the subject of extensive experimental and computational studies. However, very few of these studies have considered noise properties using mechanistic models that account for the discrete movement of ribosomes and RNA pol ...

Amer Inst Physics2015

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Daniel Constam, Benjamin Marcel Daniel Rothé, Lucía Carolina Leal Esteban, Séverine Marguerite Urfer, Florian Urs Bernet

Loss of the RNA-binding protein Bicaudal-C (Bicc1) provokes renal and pancreatic cysts as well as ectopic Wnt/beta-catenin signaling during visceral left-right patterning. Renal cysts are linked to defective silencing of Bicc1 target mRNAs, including adeny ...

American Society for Microbiology2015

Relevance of the Drag Force during Controlled Translocation of a DNA–Protein Complex through a Glass Nanocapillary

Aleksandra Radenovic, Sanjin Marion, Roman Bulushev

Combination of glass nanocapillaries with optical tweezers allowed us to detect DNA-protein complexes in physiological conditions. In this system, a protein bound to DNA is characterized by a simultaneous change of the force and ionic current signals from ...

American Chemical Society2015

Upstream Binding of Idling RNA Polymerase Modulates Transcription Initiation from a Nearby Promoter

Giovanni Dietler, Aleksandre Japaridze

The bacterial gene regulatory regions often demonstrate distinctly organized arrays of RNA polymerase binding sites of illdefined function. Previously we observed a module of closely spaced polymerase binding sites upstream of the canonical promoter of the ...

American Society for Biochemistry and Molecular Biology2015

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

Henning Paul-Julius Stahlberg

The signal recognition particle (SRP) recognizes signal sequences of nascent polypeptides and targets ribosome-nascent chain complexes to membrane translocation sites. In eukaryotes, translating ribosomes are slowed down by the Alu domain of SRP to allow e ...

Springer Nature2015

The Phosphoinositide 3-Kinase p110 alpha Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma

Pascale Anderle Pedone

Medulloblastoma (MB) is the most common malignant brain tumor in childhood and represents the main cause of cancer-related death in this age group. The phosphoinositide 3-kinase (PI3K) pathway has been shown to play an important role in the regulation of m ...

Public Library of Science2015

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RNA-dependent RNA polymerase

Single Molecule Localization and Discrimination of DNA–Protein Complexes by Controlled Translocation Through Nanocapillaries

Catalytic Metal Ions and Enzymatic Processing of DNA and RNA

Implementation and Characterization of Dynamic Genetic Networks in Vitro

Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

Noise analysis of genome-scale protein synthesis using a discrete computational model of translation

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Relevance of the Drag Force during Controlled Translocation of a DNA–Protein Complex through a Glass Nanocapillary

Upstream Binding of Idling RNA Polymerase Modulates Transcription Initiation from a Nearby Promoter

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

The Phosphoinositide 3-Kinase p110 alpha Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma

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Chat with Graph Search

Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

Noise analysis of genome-scale protein synthesis using a discrete computational model of translation

Catalytic Metal Ions and Enzymatic Processing of DNA and RNA

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Implementation and Characterization of Dynamic Genetic Networks in Vitro

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

Relevance of the Drag Force during Controlled Translocation of a DNA–Protein Complex through a Glass Nanocapillary

The Phosphoinositide 3-Kinase p110 alpha Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma

Single Molecule Localization and Discrimination of DNA–Protein Complexes by Controlled Translocation Through Nanocapillaries

Upstream Binding of Idling RNA Polymerase Modulates Transcription Initiation from a Nearby Promoter