Concept

Microarray analysis techniques

Related publications (101)

Bioimaging and Functional Genomics

For better understanding of genetic mechanisms underlying clinical observations, it is interesting to determine which genes and clinical traits are interrelated. In the last few years a consistent amount of research in genomics has been done concerning cor ...

2006

Exploiting Binary Abstractions in Deciphering Gene Interactions

Giovanni De Micheli, Abhishek Garg

We consider computationally reconstructing gene regulatory networks on top of the binary abstraction of gene expression state information. Unlike previous Boolean network approaches, the proposed method does not handle noisy gene expression values directly ...

2006

Protein function microarrays based on self-immobilizing and self-labeling fusion proteins

Harm-Anton Klok, Kai Johnsson, Stefano Tugulu, India Christina Sielaff, Anke Arnold

Protein microarrays are an attractive approach for the high-throughput analysis of protein function, but their impact on proteomics has been limited by the technical difficulties associated with their generation. Here we demonstrate that fusion proteins of ...

2006

Regional and cellular gene expression changes in human Huntington's disease brain

Darlene Goldstein, Mauro Delorenzi, Doris Chau Voo Thu, Thierry Sengstag

Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human brain has not previously been available. To elucidate the molecular phenotype of HD on a genome- ...

Oxford University Press2006

A Laplace mixture model for the identification of differential expression in microarrays

Anthony Christopher Davison, Darlene Goldstein, Yann Ruffieux

Microarrays have become an important tool for studying the molecular basis of complex disease traits and fundamental biological processes. A common purpose of microarray experiments is the detection of genes that are differentially expressed under two cond ...

2006

A Pattern-Mining Method for High-Throughput Lab-on-a-Chip Data Analysis

Giovanni De Micheli, Luca Benini

Biochips are emerging as a useful tool for high-throughput acquisition of biological data and continue to grow in information quality and in discovering new applications. Recent advances include CMOS-based integrated biosensor arrays for deoxyribonucleic a ...

Institute of Electrical and Electronics Engineers2006

In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis

Felix Naef

Neural stem cells and neurogenesis persist in the adult mammalian brain subventricular zone (SVZ). Cells born in the rodent SVZ migrate to the olfactory bulb (Ob) where they differentiate into interneurons. To determine the gene expression and functional p ...

Elsevier2006

Measuring the Performance of Face Localization Systems

Samy Bengio, Yann Rodriguez

The purpose of Face localization is to determine the coordinates of a face in a given image. It is a fundamental research area in computer vision because it serves, as a necessary first step, any face processing systems, such as automatic face recognition, ...

2006

Microarray analysis of VEGF-C responsive genes in human lymphatic endothelial cells

Melody Swartz, Carolyn Yong Pullin

Vascular endothelial growth factor-C (VEGF-C) is considered one of the most important factors influencing lymphatic endothelial cell biology. The goal of this work was to characterize the gene expression response by lymphatic endothelial cells (LECs) to VE ...

2005

Identification of molecular apocrine breast tumours by microarray analysis

Cathrin Brisken, Darlene Goldstein, Maryse Fiche

Previous microarray studies on breast cancer identified multiple tumour classes, of which the most prominent, named luminal and basal, differ in expression of the oestrogen receptor alpha gene (ER). We report here the identification of a group of breast tu ...

2005

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