Publications related to Flux (metabolism)

Kinetic reconstruction and analysis of sphingolipid metabolism

Vassily Hatzimanikatis, Howard Riezman, Georgios Savoglidis

Lipids are major constituents of the cell, implicated with its functional and structural properties, along with a number of chronic diseases. Applying computational techniques with systematic modeling of lipids can provide insights about mechanisms that re ...

2014

Characterization of intracellular metabolic states in cells presenting the Warburg phenotype

Vassily Hatzimanikatis, Joana Raquel Pinto Vieira

- Cancer cells have been shown to undergo a metabolic reprogramming (Warburg effect) characterized by enhanced glycolytic fluxes and down-regulated oxidative phosphorylation even in the presence of abundant oxygen. - Experiments show that disruption of e ...

2014

Quantitative Mass Spectrometry Reveals Plasticity of Metabolic Networks in Mycobacterium smegmatis

John McKinney, Romain Hamelin, Florence Armand, Diego Chiappe, Marc Moniatte, Tarun Chopra

Mycobacterium tuberculosis has a remarkable ability to persist within the human host as a clinically inapparent or chronically active infection. Fatty acids are thought to be an important carbon source used by the bacteria during long term infection. Catab ...

Amer Soc Biochemistry Molecular Biology Inc2014

An Efficient Drug Metabolism Strategy Based on Microsome-Mesoporous Organosilica Nanoreactors

Hubert Girault, Liang Qiao, Peng Zhang

A rapid and accurate in-vitro drug metabolism strategy has been proposed based on the design of a biomimetic nanoreactor composed of amino-functionalized periodic mesoporous organosilica (NH2-PMO) and microsomes. The amphiphilic and positive charged NH2-PM ...

Amer Chemical Soc2014

Design, development, and validation of an in-situ biosensor array for metabolite monitoring of cell cultures

Giovanni De Micheli, Sandro Carrara, Jacopo Olivo, Cristina Boero, Marco Mazza, Maria Antonietta Casulli, Lorenzo Foglia

Conventional pharmaceutical processes involving cell culture growth are generally taken under control with expensive and long laboratory tests performed by direct sampling to evaluate quality. This traditional and well-established approach is just partiall ...

Elsevier2014

Large-scale filament formation inhibits the activity of CTP synthetase

Anne-Florence Raphaëlle Bitbol, Hsin-Jung Li

Synthetase (CtpS) is a universally conserved and essential metabolic enzyme. While many enzymes form small oligomers, CtpS forms large-scale filamentous structures of unknown function in prokaryotes and eukaryotes. By simultaneously monitoring CtpS polymer ...

eLife Sciences Publications, Ltd2014

Development of mutagenicity during degradation of N-nitrosamines by advanced oxidation processes

Urs von Gunten, Kristin Schirmer, Silvio Canonica

Development of mutagenicity of five N-nitrosamines (N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA), N-nitrosodi-n-propylamine (NDPA), N-nitrosopyrrolidine (NPYR) and N-nitrosodiphenylamine (NDPhA)) was investigated during oxidative processes i ...

Elsevier2014

In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T

Rolf Gruetter, Lijing Xin, Bernard Lanz

Astrocytes have recently become a major center of interest in neurochemistry with the discoveries on their major role in brain energy metabolism. An interesting way to probe this glial contribution is given by in vivo 13C NMR spectroscopy coupled with the ...

Wiley-Blackwell2014

Transcriptional Coregulators: Fine-Tuning Metabolism

Johan Auwerx, Laurent Mouchiroud

Metabolic homeostasis requires that cellular energy levels are adapted to environmental cues. This adaptation is largely regulated at the transcriptional level, through the interaction between transcription factors, coregulators, and the basal transcriptio ...

Elsevier2014

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Flux (metabolism)

Kinetic reconstruction and analysis of sphingolipid metabolism

Characterization of intracellular metabolic states in cells presenting the Warburg phenotype

Quantitative Mass Spectrometry Reveals Plasticity of Metabolic Networks in Mycobacterium smegmatis

Targeting Bacterial Central Metabolism for Drug Development

An Efficient Drug Metabolism Strategy Based on Microsome-Mesoporous Organosilica Nanoreactors

Design, development, and validation of an in-situ biosensor array for metabolite monitoring of cell cultures

Large-scale filament formation inhibits the activity of CTP synthetase

Development of mutagenicity during degradation of N-nitrosamines by advanced oxidation processes

In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T

Transcriptional Coregulators: Fine-Tuning Metabolism

Graph Chatbot

Chat with Graph Search

Characterization of intracellular metabolic states in cells presenting the Warburg phenotype

Kinetic reconstruction and analysis of sphingolipid metabolism

An Efficient Drug Metabolism Strategy Based on Microsome-Mesoporous Organosilica Nanoreactors

Quantitative Mass Spectrometry Reveals Plasticity of Metabolic Networks in Mycobacterium smegmatis

Targeting Bacterial Central Metabolism for Drug Development

Transcriptional Coregulators: Fine-Tuning Metabolism

Development of mutagenicity during degradation of N-nitrosamines by advanced oxidation processes

Large-scale filament formation inhibits the activity of CTP synthetase

In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T

Design, development, and validation of an in-situ biosensor array for metabolite monitoring of cell cultures