Publications related to Synaptic vesicle

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

Henry Markram, Srikanth Ramaswamy, Daniel Keller, Cristina Colangelo, Polina Shichkova

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically rec ...

FRONTIERS MEDIA SA2019

Regulation of adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals

Ursula Röthlisberger, Siri Camee van Keulen, Daniele Narzi, Paolo Carloni

Author summary Adenylyl cyclases (ACs) are enzymes that can translate extracellular signals into the intracellular molecule cAMP, which is thus a 2nd messenger of extracellular events. The brain expresses nine membrane-bound AC variants, and AC5 is the dom ...

PUBLIC LIBRARY SCIENCE2019

Optimal Stimulation Protocol in a Bistable Synaptic Consolidation Model

Wulfram Gerstner, Samuel Pavio Muscinelli, Chiara Gastaldi

Synaptic changes induced by neural activity need to be consolidated to maintain memory over a timescale of hours. In experiments, synaptic consolidation can be induced by repeating a stimulation protocol several times and the effectiveness of consolidation ...

FRONTIERS MEDIA SA2019

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

Jean-Philippe Thiran, Graham Knott, Maxime Descoteaux, Giorgio Innocenti, Tim Bjørn Dyrby

The axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological ...

OXFORD UNIV PRESS INC2019

Membrane–Protein–Hydration Interaction of α-Synuclein with Anionic Vesicles Probed via Angle-Resolved Second-Harmonic Scattering

Sylvie Roke, Jan Dedic, Halil Ibrahim Okur

Amyloid formation of the protein α-synuclein promotes neurodegeneration in Parkinson's disease. The normal function of α-synuclein includes synaptic vesicle transport and fusion, and the protein binds strongly to negatively charged vesicles in vitro. Here, ...

2019

A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology

Sameer Mohammad Khaleel Nazeeruddin

Tauopathies are neurodegenerative diseases whose common pathological feature is the intraneuronal accumulation of tau aggregates. Tau protein has various roles in the neuron, among which stabilization of microtubules (MT), regulation of synaptic activity o ...

EPFL2019

The gut microbiota influences skeletal muscle mass and function in mice

Johan Auwerx, Hongbo Zhang, Walter Wahli

The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free ...

AMER ASSOC ADVANCEMENT SCIENCE2019

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Steinunn Baekkeskov Hanahan, Chiara Cianciaruso, Petra Catalina Schwalie, Edward Allen Phelps

Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (gamma-aminobutyric acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet homeostasis. Islet GABA release has classically been described as a secretory- ...

2019

Templating colloidal sieves for tuning nanotube surface interactions and optical sensor responses

Ardemis Anoush Boghossian, Benjamin Paul Johanès Gabriel Lambert, Daniel Jerôme Siefman, Alice Judith Gillen, Shang-Jung Wu

Surfactants offer a tunable approach for modulating the exposed surface area of a nanoparticle. They further present a scalable and cost-effective means for suspending single-walled carbon nanotubes (SWCNTs), which have demonstrated practical use as fluore ...

2019

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Synaptic vesicle

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

Regulation of adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals

Optimal Stimulation Protocol in a Bistable Synaptic Consolidation Model

Photoregulated fluxional fluorophores for live-cell super-resolution microscopy with no apparent photobleaching

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

Membrane–Protein–Hydration Interaction of α-Synuclein with Anionic Vesicles Probed via Angle-Resolved Second-Harmonic Scattering

A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology

The gut microbiota influences skeletal muscle mass and function in mice

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Templating colloidal sieves for tuning nanotube surface interactions and optical sensor responses

Graph Chatbot

Chat with Graph Search

The gut microbiota influences skeletal muscle mass and function in mice

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

Photoregulated fluxional fluorophores for live-cell super-resolution microscopy with no apparent photobleaching

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

Membrane–Protein–Hydration Interaction of α-Synuclein with Anionic Vesicles Probed via Angle-Resolved Second-Harmonic Scattering

Optimal Stimulation Protocol in a Bistable Synaptic Consolidation Model

Templating colloidal sieves for tuning nanotube surface interactions and optical sensor responses

Regulation of adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals

A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology