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During active TB in humans a spectrum of pulmonary granulomas with central necrosis and hypoxia exists. BALB/c mice, predominantly used in TB drug development, do not reproduce this complex pathology thereby inaccurately predicting clinical outcome. We fou ...
Neutrophils are leukocytes that play a key role in innate immunity. Their mode of action in case of infection is well described, but their impact in different chronic diseases, such as cancer, remains unclear. Nevertheless, recent publications describe neu ...
Kessler et al. identify aberrant DNA recognition by cGAS/STING and IFN-I production by inflammatory macrophages as a driver of severe ANCA-associated vasculitis. Pharmacological interventions blocking this pathway ameliorate disease and accelerate recovery ...
Background: Angiogenesis is widely investigated in conjunction with cancer development, in particular because of the possibility of early stage detection and of new therapeutic strategies. However, such studies are negatively affected by the limitations of ...
Vanadium oxide nanotubes with a diameter of 20-100 nm and an aspect ratio of 50-100 were synthesized by hydrothermal method. Young's modulus of 20-80 GPa was obtained by bending measurements of individual nanotubes using an atomic force microscope. Electri ...
