Publications related to Experimental evolution

Cyclic peptide therapeutics: past, present and future

Cyclic peptides combine several favorable properties such as good binding affinity, target selectivity and low toxicity that make them an attractive modality for the development of therapeutics. Over 40 cyclic peptide drugs are currently in clinical use an ...

2017

An Approximate Markov Model for the Wright-Fisher Diffusion and Its Application to Time Series Data

Jeffrey David Jensen, Anna Ferrer Admetlla

The joint and accurate inference of selection and demography from genetic data is considered a particularly challenging question in population genetics, since both process may lead to very similar patterns of genetic diversity. However, additional informat ...

Genetics Society America2016

Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory

Luciano Andres Abriata

The understanding of protein evolution depends on the ability to relate the impact of mutations on molecular traits to organismal fitness. Biological activity and robustness have been regarded as important features in shaping protein evolutionary landscape ...

Oxford Univ Press2016

Echovirus 11 mutants with increased resistance to common water disinfectants

Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann, Qingxia Zhong

Common water disinfectants like chlorine have been reported to select for resistant viruses. Yet, only little attention has been devoted to characterizing disinfection resistance. The goal of this study was to produce disinfectant-resistant viruses and to ...

2016

Echovirus 11 mutants with increased resistance to common water disinfectants

Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann, Qingxia Zhong

Common water disinfectants like chlorine have been reported to select for resistant viruses. Yet, only little attention has been devoted to characterizing disinfection resistance. The goal of this study was to produce disinfectant-resistant viruses and to ...

2016

A Statistical Guide to the Design of Deep Mutational Scanning Experiments

Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski

The characterization of the distribution of mutational effects is a key goal in evolutionary biology. Recently developed deep-sequencing approaches allow for accurate and simultaneous estimation of the fitness effects of hundreds of engineered mutations by ...

Genetics Society America2016

On the (un) predictability of a large intragenic fitness landscape

Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski

The study of fitness landscapes, which aims at mapping genotypes to fitness, is receiving ever-increasing attention. Novel experimental approaches combined with next-generation sequencing (NGS) methods enable accurate and extensive studies of the fitness e ...

Natl Acad Sciences2016

An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

Jeffrey David Jensen, Matthieu Foll, Claudia Bank, Sebastian Matuszewski, Hyunjin Shim

The rapid evolution of drug resistance remains a critical public health concern. The treatment of influenza A virus (IAV) has proven particularly challenging, due to the ability of the virus to develop resistance against current antivirals and vaccines. He ...

Wiley-Blackwell2016

NEMo: An Evolutionary Model with Modularity for PPI Networks

Bernard Moret, Xiuwei Zhang, Min Ye, Qijia Jiang, Gabriela Clara Racz

Modelling the evolution of biological networks is a major challenge. Biological networks are usually represented as graphs; evolutionary events include addition and removal of vertices and edges, but also duplication of vertices and their associated edges. ...

Springer Int Publishing Ag2016

A molecular chaperone dedicated to folding and translocation of reductive dehalogenases

Julien Maillard, Corantin Grob

Reductive dehalogenases (rdhA, RDases) are key enzymes involved in anaerobic organohalide respiration (OHR), during which bacteria are able to use chlorinated compounds as terminal electron acceptors. RDases are redox enzymes containing FeS clusters and a ...

2016

Experimental evolution

Cyclic peptide therapeutics: past, present and future

An Approximate Markov Model for the Wright-Fisher Diffusion and Its Application to Time Series Data

Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory

Echovirus 11 mutants with increased resistance to common water disinfectants

Echovirus 11 mutants with increased resistance to common water disinfectants

A Statistical Guide to the Design of Deep Mutational Scanning Experiments

On the (un) predictability of a large intragenic fitness landscape

An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

NEMo: An Evolutionary Model with Modularity for PPI Networks

A molecular chaperone dedicated to folding and translocation of reductive dehalogenases

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NEMo: An Evolutionary Model with Modularity for PPI Networks

Cyclic peptide therapeutics: past, present and future

An Approximate Markov Model for the Wright-Fisher Diffusion and Its Application to Time Series Data

Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory

A Statistical Guide to the Design of Deep Mutational Scanning Experiments

Echovirus 11 mutants with increased resistance to common water disinfectants

Echovirus 11 mutants with increased resistance to common water disinfectants

A molecular chaperone dedicated to folding and translocation of reductive dehalogenases

On the (un) predictability of a large intragenic fitness landscape

An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy