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Chemical modification of phage libraries has allowed the in vitro evolution of ligands having properties not provided by natural polypeptides. The development of novel and more diverse chemical reactions on phage was hampered by the lack of analytical meth ...
We present a detailed study on the charge ordering transition in a GdBaCo2O5.0 system by combining highresolution synchrotron powder/single-crystal diffraction with electron paramagnetic resonance experiments as a function of temperature. We found a second ...
Characterizing the role of effective population size in dictating the rate of adaptive evolution remains a major challenge in evolutionary biology. Depending on the underlying distribution of fitness effects of new mutations, populations of different sizes ...
This document summarizes adaptation experiments done on French MediaParl corpus and other French corpora. Baseline adaptation techniques are briefly presented and evaluated in the MediaParl task for speaker adaptation, speaker adaptive training, database c ...
One of the key innovations during the evolution of life on earth has been the emergence of efficient communication systems, yet little is known about the causes and consequences of the great diversity within and between species. By conducting experimental ...
To understand how organisms adapt to novel habitats, which involves both demographic and selective events, we require knowledge of the evolutionary history of populations and also selected alleles. There are still few cases in which the precise mutations ( ...
Evolutionary algorithms were proposed to automatically find solutions to computational problems, much like evolution discovers new adaptive traits. Lately, they have been used to address challenging questions about the evolution of modularity, the genetic ...
The evolution of altruism is a fundamental and enduring puzzle in biology. In a seminal paper Hamilton showed that altruism can be selected for when rb − c>0, where c is the fitness cost to the altruist, b is the fitness benefit to the beneficiary, and r i ...
Transcription factor binding site(s) (TFBS) gain and loss (i.e., turnover) is a well-documented feature of cis-regulatory module (CRM) evolution, yet little attention has been paid to the evolutionary force(s) driving this turnover process. The predominant ...
Alternative splicing, an unknown mechanism 20 years ago, is now recognized as a major mechanism for proteome and transcriptome diversity, particularly in mammals - some researchers conjecture that up to 90% of human genes are alternatively spliced. Despite ...