Concept

Thermosynthesis

Summary
Thermosynthesis is a theoretical mechanism proposed by Anthonie Muller for biological use of the free energy in a temperature gradient to drive energetically uphill anabolic reactions. It makes use of this thermal gradient, or the dissipative structure of convection in this gradient, to drive a microscopic heat engine that performs condensation reactions. Thus negative entropy is generated. The components of the biological thermosynthesis machinery concern progenitors of today's ATP synthase, which functions according to the binding change mechanism, driven by chemiosmosis. Resembling primitive free energy generating physico-chemical processes based on temperature-dependent adsorption to inorganic materials such as clay, this simple type of energy conversion is proposed to have sustained the origin of life, including the emergence of the RNA World. For this RNA World it gives a model that describes the stepwise acquisition of the set of transfer RNAs that sustains the Genetic code. The
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