Concept
Glutathione
Related publications (68)
HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology
Redox homeostasis is a key factor in maintaining cellular function and health. The main determinant of the intracellular redox potential is ubiquitous glutathione (GSH) together with its oxidized dimer (GSSG). Importantly, both redox equilibrium and GSH ho ...
EPFL2024Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia
Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva
Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...
2024High-Density Immobilization of TCEP on Silica Beads for Efficient Disulfide Reduction and Thiol Alkylation in Peptides
Tris-(2-carboxyethyl)phosphine (TCEP) linked to agarose beads is widely used for reducing disulfide bridges in proteins and peptides. The immobilization of TCEP on beads allows efficient removal after reduction to prevent its reaction with alkylating reage ...
Weinheim2023A locally activatable sensor for robust quantification of organellar glutathione
Pablo Rivera Fuentes, Sarah Emmert, Gianluca Quargnali
Glutathione (GSH) is the main determinant of intracellular redox potential and participates in multiple cellular signalling pathways. Achieving a detailed understanding of intracellular GSH homeostasis depends on the development of tools to map GSH compart ...
NATURE PORTFOLIO2023Modulation of Subcellular Redox Homeostasis with Trialkylphosphines
Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced (GSH) and oxidized (GSSG) glutathione. In eukaryotic cells, this ratio ...
SWISS CHEMICAL SOC2022Article Structure and functionality of a multimeric human COQ7:COQ9 complex
Matteo Dal Peraro, Luciano Andres Abriata
Coenzyme Q (CoQ) is a redox-active lipid essential for core metabolic pathways and antioxidant defense. CoQ is synthesized upon the mitochondrial inner membrane by an ill-defined "complex Q" metabolon. Here, we present structure-function analyses of a lipi ...
CELL PRESS2022Automated approach for the evaluation of glutathione-S-transferase P1-1 inhibition by organometallic anticancer compounds
Paul Joseph Dyson, Sarah Alexandra Pais Pereira
A novel automated method based on sequential injection analysis (SIA), a non-segmented flow injection technique, was developed to evaluate glutathione S-transferase P1-1 (GST P1-1) activity in the presence of organometallic complexes with putative anticanc ...
TAYLOR & FRANCIS LTD2022Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase
Christian Heinis, Manuel Leonardo Merz, Sevan Mleh Habeshian, Ganesh Ashokrao Sable
The synthesis of large numbers of cyclic peptides-required, for example, in screens for drug development-is currently limited by the need of chromatographic purification of individual peptides. Herein, we have developed a strategy in which cyclic peptides ...
AMER CHEMICAL SOC2022Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort
Maria del Carmen Sandi Perez, Lijing Xin, Olivia Zanoletti, Simone Astori, João Pedro de Matos Rodrigues, Fiona Hollis, Pascal Steiner, Ioannis Zalachoras, Alina Veronika Irene Strasser, Eva Ramos Fernandez
Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens in motivated performance. However, the brain is vulnerable to excessive oxidative insults resulting from neurometabolic processes, and whether antioxidant level ...
2022Disruption of mitochondrial redox homeostasis by enzymatic activation of a trialkylphosphine probe
Pablo Rivera Fuentes, Jade Noémie Nam Nguyen
Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced and oxidized glutathione. In eukaryotic cells, this ratio is different ...
ROYAL SOC CHEMISTRY2021