The Correlation between Relatives on the Supposition of Mendelian Inheritance
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Natural populations present an abundant genetic variability. Like mutation or natural se- lection, dierent processes are at stake to generate this variability. Population genetics is a topic that emerged in the late 40's, thanks mainly to the biologists Fi ...
Mendelian randomization is the use of genetic variants to assess the effect of intervening on a risk factor using observational data. We consider the scenario in which there is a pharmacomimetic (i.e., treatment-mimicking) genetic variant that can be used ...
Many genes and pathways have been linked to aging, yet our understanding of underlying molecular mechanisms is still lacking. Here, we measure changes in the transcriptome, histone modifications, and DNA methylome in three metabolic tissues of adult and ag ...
Generalized algebraic data types (GADT) have been notoriously difficult to implement correctly in Scala. Both major Scala compilers, Scalac and Dotty, are currently known to have type soundness holes related to them. In particular, covariant GADTs have exp ...
As the focus of human genetics shifts from Mendelian traits to complex diseases, a sophisticated genetic tool kit—with space for genetics (classical, molecular, statistical, and quantitative), metabolics, proteomics, bioinformatics, and mathematics—is requ ...