Concept

Retinal detachment

Related publications (110)

Active Vision and Feature Selection in Evolutionary Behavioral Systems

We describe an evolutionary approach to active vision systems for dynamic feature selection. After summarizing recent work on evolution of a simulated active retina for complex shape discrimination, we describe in detail experiments that extend this approa ...

2002

Influence of tyrosinase levels on pigment accumulation in the retinal pigment epithelium and on the uncrossed retinal projection

Friedrich Beermann

To study the relationship among tyrosinase activity, melanin production, and the routing of retinal ganglion cell (RGC) axons at the optic chiasm, we analysed mice with varying doses of the tyrosinase gene. These include the dark-eyed albino (Tyrc44H), a r ...

2002

Verteporfin therapy of subfoveal choroidal neovascularization in patients with age-related macular degeneration: additional information regarding baseline lesion composition's impact on vision outcomes-TAP report No. 3

OBJECTIVE: To explore how baseline lesion composition influenced vision outcomes in patients with age-related macular degeneration (AMD) undergoing photodynamic therapy with verteporfin (Visudyne) for subfoveal choroidal neovascularization (CNV) in the Tre ...

2002

Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE

Friedrich Beermann

We have analysed the importance of fibroblast growth factor 2 (FGF2) in tumor development. In a transgenic mouse model (Tyrp1-Tag) tumors form in the retinal pigment epithelium (RPE), invade surrounding tissues, and metastasize to lymph node and spleen. To ...

2002

Increased transgene expression by the mouse tyrosinase enhancer is restricted to neural crest-derived pigment cells

Friedrich Beermann

In this study, we have addressed the impact of the mouse tyrosinase enhancer on regulated expression from the mouse tyrosinase promoter during embryonic development. Stable and transient transgenic experiments using the reporter gene lacZ reveal that (1) e ...

2001

Ectopic expression of RET results in microphthalmia and tumors in the retinal pigment epithelium

Friedrich Beermann

The retinal pigment epithelium (RPE) is essential for eye development by interacting with the overlaying neuroepithelium. Regulatory sequences of the gene encoding for tyrosinase-related protein 1 (TRP- 1), linked to the lacZ reporter gene, lead to strong ...

1999

Identification of the optic disk boundary in retinal images using active contours

Jean-Philippe Thiran, François Mendels

This paper describes a technique for identifying the boundary of the optic disk in digital images of the retina, using an approach based on active contours (snakes). The optic disk is the region on the retina at which optic nerve axons enter and leave the ...

IEEE1999

Transgenic mouse models for tumors of melanocytes and retinal pigment epithelium

Friedrich Beermann

Cutaneous and ocular melanomas are due to malignant transformation of neural crest-derived melanocytes. The rising incidence of this tumor in humans has stimulated experiments to devise suitable mouse models. In the past years, transgenic mouse lines have ...

1999

Misrouting of tyrosinase with a truncated cytoplasmic tail as a result of the murine platinum (cp) mutation

Friedrich Beermann

Mice homozygous for the platinum (cp) allele at the albino locus manifest severe oculocutaneous albinism despite the presence in vitro of tyrosinase activity at 25% wild-type levels. We demonstrate that the cp allele results from an A-->T substitution, cha ...

1995

Differential effects of benzamides and thioxanthenes on dopamine-elicited accumulation of cyclic AMP in isolated rabbit retina

Pierre Magistretti

Benzamides or thioxanthenes were tested as potential antagonists of the cyclic AMP accumulation induced by 10(-4) M dopamine in intact rabbit retinae in vitro in the presence of 5 to 7 mM theophylline. The neuroleptic sulpiride (10(-4) M) was found to be t ...

1978

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