Concept

Tax gene product

Summary
A Tax Gene Product (Tax) is a nuclear protein that has a molecular weight of about 37,000 to 40,000 daltons. Tax gene Tax is produced by members of the retroviral family primate T-lymphotropic virus, which are classified as Deltaretroviruses. This includes Human T-lymphotrophic viruses (HTLVs), bovine leukaemia virus (BLV) and simian T-lymphotropic viruses (STLVs). The tax protein produced from HTLV-1 and HTLV-2 have been most extensively studied. The gene for Tax is found within the pX region between the env gene and one of the long terminal repeats of the viral genome; which is where the name Tax comes from (transactivator from the X-gene region). Tax acts as a transactivator, causing the transcription (production of mRNA from genetic code) of viral proteins in the long terminal repeat that are essential for replication. Role in disease HTLV-1 causes an aggressive form of leukaemia: adult T cell leukaemia (ATL), and Tax has largely been implicated in the oncogeni
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