Concept

Malabsorption

Related publications (32)

Analysis of mice with conditional ferritin H deletion

Iron is a transitional metal required by virtually all organisms as a dietary micromineral, indispensable for cellular survival and proliferation. The management of iron absorption and distribution in the organism and inside the cell must be tightly regula ...

EPFL2009

Effect of microcapsule composition and short-term immunosuppression on intraportal biocompatibility

Jutta Christine Wandrey, David Hunkeler, Dianelys Sainz Vidal

With higher nutrient and oxygen supply and close contact to blood, the portal vein is a possible alternative to the peritoneal cavity for transplantation of encapsulated cells. Data regarding intraportal biocompatibility of microcapsules are lacking. Micro ...

2005

Acetate production from lactose by Clostridium thermolacticum and hydrogen-scavenging microorganisms in continuous culture - Effect of hydrogen partial pressure

Jean-Paul Schwitzguebel, Christophe Collet

The effect of the addition of hydrogen-consuming microorganisms on the metabolism of Clostridium thermolacticum was studied. By growing this bacterium in continuous culture at 58 degrees C, on 29 mmol lactose l(-1) (10 g l(-1)) in the feed, with the H-2-co ...

2005

Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/-) mice

Johan Auwerx

We evaluated the effects of E2F1 on glucose homeostasis using E2F1(-/-) mice. E2F1(-/-) mice show an overall reduction in pancreatic size as the result of impaired postnatal pancreatic growth. Furthermore, these animals have dysfunctional beta cells, linke ...

2004

Scanning tunneling microscopy of self-organized semiconductor quantum dots

This thesis is committed to the study of nanometer scale surface processes involved in the formation and evolution of self-organized semiconductor quantum dots. The aim is to contribute to a better understanding of the mechanisms influencing the final shap ...

EPFL2004

The enterohepatic nuclear receptors are major regulators of the enterohepatic circulation of bile salts

Johan Auwerx

Recent studies have established that bile salts are signaling molecules, besides their classic function in dietary lipid absorption and cholesterol metabolism. Bile salts signal by activating mitogen-activated protein kinase (MAPK) pathways and nuclear rec ...

2004

Cholesterol metabolism modulators and the future of atherosclerosis therapy [Modulateurs du métabolisme du cholestérol et avenir du traitement de l’athérosclérose]

Johan Auwerx

Atherosclerosis is a disease characterized by lipid accumulation in the vascular wall leading to myocardial infarction or stroke. Hypercholesterolemia is an important risk factor and current treatments are largely based on cholesterol lowering. In spite of ...

2004

Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis

Johan Auwerx, Mehdi Karoui

BACKGROUND & AIMS: The peroxisome proliferator-activated receptor gamma (PPAR gamma) has been proposed as a key inhibitor of colitis through attenuation of nuclear factor kappa B (NF-kappa B) activity. In inflammatory bowel disease, activators of NF-kappa ...

2003

Liver X receptors: Xcreting Xol to combat atherosclerosis

Johan Auwerx

Liver X receptors (LXRs) are nuclear receptors that act as metabolic sensors for cellular cholesterol (Xol) and oxysterol content. Increased oxysterol levels activate LXRs, which then induce: the removal of cholesterol out of peripheral cells; transport of ...

2002

Carbohydrate-deficient glycoprotein syndrome 1b: a new answer to an old diagnostic dilemma

A patient with carbohydrate-deficient glycoprotein syndrome type 1b (CDGS1b) is reported. The patient presented at 5 months of age with failure to thrive, prolonged diarrhoea, hepatomegaly and elevated serum liver transaminases. Liver biopsy showed steatos ...

Department of Gastroenterology, Royal Children's Hospital, Parkville, Victoria, Australia2001

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