Concept

Lymph node

Related publications (191)

Intravital Immunofluorescence for Visualizing the Microcirculatory and Immune Microenvironments in the Mouse Ear Dermis

Melody Swartz, Witold Waldemar Kilarski, Amanda Waite Lund, Jeremy Teo, Scott Oliver

Visualizing the dynamic behaviors of immune cells in living tissue has dramatically increased our understanding of how cells interact with their surroundings, contributing important insights into mechanisms of leukocyte trafficking, tumor cell invasion, an ...

Public Library of Science2013

Highly Dynamic Distributed Computing with Byzantine Failures

Rachid Guerraoui, Anne-Marie Kermarrec, Florian Huc

This paper shows for the first time that distributed computing can be both reliable and efficient in an environment that is both highly dynamic and hostile. More specifically, we show how to maintain clusters of size O(log N), each containing more than two ...

2013

Aptamer-Functionalized, Ultra-Small, Monodisperse Silica Nanoconjugates for Targeted Dual-Modal Imaging of Lymph Nodes with Metastatic Tumors

Li Tang

A dual-modal imaging probe based on size-controlled silica nanoconjugates was synthesized for targeted imaging of lymph nodes by means of both PET and near infrared fluorescence techniques. 20 nm nanoconjugates (see scheme) functionalized with an aptamer ( ...

Wiley-Blackwell2012

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

Melody Swartz, Sachiko Hirosue, Amanda Waite Lund, Susan Thomas, Amine Issa, Vidya Raghavan

Tumor expression of the lymphangiogenic factor VEGF-C is correlated with metastasis and poor prognosis, and although VEGF-C enhances transport to the draining lymph node (dLN) and antigen exposure to the adaptive immune system, its role in tumor immunity r ...

Elsevier2012

Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage

Melody Swartz, Joseph Rutkowski, Miriella Carmela Pasquier, Susan Thomas

Lymphatic vessels transport interstitial fluid, soluble Ag, and immune cells from peripheral tissues to lymph nodes (LNs), yet the contribution of peripheral lymphatic drainage to adaptive immunity remains poorly understood. We examined immune responses to ...

Amer Assoc Immunologists2012

Interstitial Fluid And Lymph Formation And Transport: Physiological Regulation And Roles In Inflammation And Cancer

Melody Swartz

Wiig H, Swartz MA. Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer. Physiol Rev 92: 1005-1060, 2012; doi: 10.1152/physrev.00037.2011.-The interstitium describes the fluid, proteins, solute ...

2012

Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Conlin O'Neil, Karen Dane, Jackson Eby

Poly(ethylene glycol)-stabilized poly(propylene sulfide) core (PEG-PPS) nanoparticles (NPs) smaller than 50 nm efficiently travel to draining lymph nodes and interact with antigen-presenting cells (APCs) to induce potent immune responses following intrader ...

Elsevier Sci Ltd2012

Therapeutic Immunomodulation of the Lymphoid-like Tumor Environment Using Nanoparticulate Formulations

Iraklis Kourtis

Cancer is a leading cause of death worldwide. Understanding the underlying mechanisms that lead to tumor escape and evasion is pivotal for the design of new therapeutic applications. This thesis takes an immunobioengineering approach, and navigates through ...

EPFL2012

Evaluation of Atlas Fusion Strategies for Segmentation of Head and Neck Lymph Nodes for Radiotherapy Planning

Jean-Philippe Thiran, Meritxell Bach Cuadra, Subrahmanyam Venkata Ravi Mohana Sai Gorthi

Accurate segmentation of lymph nodes in head and neck (H&N) CT images is essential for the radiotherapy planning of the H&N cancer. Atlas-based segmentation methods are widely used for the automated segmentation of such structures. Multi-atlas approaches a ...

Ieee2012

Carcinogen treatment in mouse selectively expressing activated N-Ras(Q61K) in melanocytes recapitulates metastatic cutaneous melanoma development

Friedrich Beermann

The incidence of melanoma has significantly increased and a better understanding its pathogenesis and development of new therapeutic strategies are urgently needed. Here we describe a murine model of metastatic cutaneous melanoma using C57BL/6 mice express ...

2012

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