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Paul M. Bingham
Summary
Paul Montgomery Bingham (born February 25, 1951) is an American molecular biologist and evolutionary biologist, Associate Professor in the Department of Biochemistry and Cell Biology at Stony Brook University and Vice President for Research at Rafael Pharmaceuticals. He is known for his work in molecular biology, and has also published recent articles and a book on human evolution.
Bingham received his undergraduate degree at Blackburn College in Carlinville, Illinois, and then completed his PhD in Biochemistry and Molecular Biology at Harvard University in 1980 (thesis advisor, Matthew Meselson) after completing an MS in Microbiology at the University of Illinois (with John W. Drake). He spent two years at the National Institute of Environmental Health Sciences (NIEHS) before joining the faculty of the Department of Biochemistry and Cell Biology and the School of Medicine at Stony Brook University in 1982.
He was part of a collaborative team that discovered the parasitic DNA sequence element, the P element transposon. This enabled a widely used strategy still used today for retrieving genes from animals. It also shed fundamental new light on how evolution shapes the (self-interested) individual genes that collaborate to build organisms.
With his wife (Zuzana Zachar), he demonstrated that transposon insertion mutations were responsible for most of the alleles used in the development of classical genetics. He also collaborated with Carl Wu and Sarah Elgin (then at Harvard) on fundamental properties of metazoan chromatin structure. In collaboration with Margaret Kidwell, then at Brown University, and Gerry Rubin, then at the Carnegie Institution, he carried out the molecular cloning of the P element transposon in Drosophila. This work revolutionized the retrieval of genes in Drosophila and subsequently contributed to progress in metazoan molecular and developmental genetics. He and his collaborators were the first to propose the use of P element transposon tagging to clone the first metazoan RNA polymerase subunit.
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