Concept

Paracetamol

Related publications (19)

In vivo metabolic studies in skeletal and cardiac muscle using ¹³C magnetic resonance spectroscopy

Cardiac and skeletal muscle function relies on a continuous energy production via fatty acid metabolism and mitochondrial oxidation of pyruvate, with a fine balance between substrate delivery and utilization. Changes in metabolism are increasingly being im ...

EPFL2013

Acute Caffeine Administration Impact On Working Memory-Related Brain Activation And Functional Connectivity In The Elderly: A Bold And Perfusion Mri Study

Dimitri Nestor Alice Van De Ville, David Moser

In young individuals, caffeine-mediated blockade of adenosine receptors and vasoconstriction has direct repercussions on task-related activations, changes in functional connectivity, as well as global vascular effects. To date, no study has explored the ef ...

Elsevier2013

N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development

Rolf Gruetter, João Miguel das Neves Duarte, Kim Do

Background: Glutathione (GSH) is the major cellular redox-regulator and antioxidant. Redox-imbalance due to genetically impaired GSH synthesis is among the risk factors for schizophrenia. Here we used a mouse model with chronic GSH deficit induced by knock ...

2012

Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats

Rolf Gruetter, Cristina Ramona Cudalbu, Arnaud Comment, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau

The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced vi ...

2010

Characterisation of Hospital Wastewater: the Case of the CHUV

Laura Marie Blanc

The aim of this study was to characterize hospital effluents in investigating the CHUV importance as source of pollutants, the range and amounts of pharmaceuticals that are used in the hospital and the need of source treatment of the hospital sewage. The C ...

2010

Intercellular calcium dynamics in smooth muscle cells

Dominique Seppey

Muscular arteries are able to actively modify their diameter by modulating the tone of the smooth muscle cells located within the arterial wall. A small variation of lumen diameter has a large influence on blood flow as well as on arterial pressure. The ca ...

EPFL2009

Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes

Didier Trono

BACKGROUND/AIMS: Liver failure is a life threatening condition currently treated by palliative measures and, when applicable, organ transplantation. The use of a bioartificial organ capable of fulfilling the main functions of the liver would represent an a ...

Elsevier2005

Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose

Rolf Gruetter

Cerebral metabolism of D[1-13C]glucose was studied with localized 13C NMR spectroscopy during intravenous infusion of enriched [1-13C]glucose in four healthy subjects. The use of three-dimensional localization resulted in the complete elimination of triacy ...

1994

A one-pot synthesis of ibuprofen involving three consecutive steps of superbase metalation

A one-pot reaction sequence consisting of three consecutive metalation and electrophilic substitution stages starting with p-xylene leads to 2-(4-isobutylphenyl)propanoic acid with a 52% overall yield. A crucial step is the alkylation of deprotonated p-eth ...

1991

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