Concept
Acute lymphoblastic leukemia
Related publications (71)
Novel quantitative bioengineered tools to track human bone marrow niche cellular constituents in health and disease
Acute leukemia has a high mortality rate of approximately 50%, and current methods are not effective in predicting disease progression and relapse. To improve our understanding of hematopoiesis and develop new markers for predicting disease relapse in dead ...
EPFL2023Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy caused by acquisition of genetic alterations during T-cell development. The 5-year overall survival of pediatric T-ALL patients has improved considerably over the past 30 ...
EPFL2023Longitudinal evaluation of the mechanisms supporting post-stroke motor recovery using TMS-EEG coupling
Andéol Geoffroy Cadic-Melchior
Stroke is the main source of long-lasting disability, affecting dominantly motor functions. The extent and course of recovery are highly heterogeneous between patients, with a minority of patients fully recovering from their initial impairments, leaving 85 ...
EPFL2023Evaluation of tire tread particle toxicity to fish using rainbow trout cell lines
Kristin Schirmer, Florian Frédéric Vincent Breider, Benoît Jean Dominique Ferrari, Thibault Béranger Masset, Gabrielle Léger
Tire and road wear particles (TRWP) resulting from tire abrasion while driving raise concerns due to their potential contribution to aquatic toxicity. Our study aimed to assess cryogenically milled tire tread (CMTT) particle toxicity, used as a proxy for T ...
2023Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL
Freddy Radtke, Ute Koch, Nadine Fournier, Marianne Nkosi, Christelle Dubey, Mateusz Waldemar Antoszewski, Tara Kimberly Sugrue, Giovanni Ciriello
NOTCH1 is a well-established lineage specifier for T cells and among the most frequently mutated genes throughout all subclasses of T cell acute lymphoblastic leukemia (T-ALL). How oncogenic NOTCH1 signaling launches a leukemia-prone chromatin landscape du ...
AMER SOC HEMATOLOGY2022Steps parameters of elderly patients hospitalised for an acute medical illness in a Swiss University Hospital: an observational pilot study
Anisoara Ionescu, Francesco Tommasini
BACKGROUND: Objective mobility goals for elderly hospitalised medical patients remain debated. We therefore studied steps parameters of elderly patients hospitalised for an acute illness, to determine goals for future interventional trials and medical prac ...
SMW supporting association2022Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors
Notch1 receptor signaling is essential for T cell fate specification and physiological thymic T lymphocyte development. Its dysregulation and oncogenic activation are detected in almost 80% of pediatric patients suffering from T cell acute lymphoblastic le ...
EPFL2021Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1(T315I) and BCR-ABL1(T315I-E255K)
Resistance remains the major clinical challenge for the therapy of Philadelphia chromosome-positive (Ph+) leukemia. With the exception of ponatinib, all approved tyrosine kinase inhibitors (TKIs) are unable to inhibit the common "gatekeeper" mutation T315I ...
SPRINGER2021Notch signaling promotes disease initiation and progression in murine chronic lymphocytic leukemia
Freddy Radtke, Ute Koch, Nadine Fournier, Jessica Sordet, Marianne Nkosi, Delphine Maude Tardivon, Mateusz Waldemar Antoszewski
NOTCH1 gain-of-function mutations are recurrent in B-cell chronic lymphocytic leukemia (B-CLL), where they are associated with accelerated disease progression and refractoriness to chemotherapy. The specific role of NOTCH1 in the development and progressio ...
AMER SOC HEMATOLOGY2021In vitro acute toxicity assessment of tire tread particles using rainbow trout cell lines of gill and intestine
Kristin Schirmer, Florian Frédéric Vincent Breider, Benoît Jean Dominique Ferrari, Thibault Béranger Masset
Tire and road wear particles (TRWP) are generated by the abrasion of tires while driving, and recent questions were raised in regards to their potential contribution to microplastics released into the aquatic environment and their potential toxicological i ...
2021