Concept

Fragment antigen-binding

Related publications (48)

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

Rolf Gruetter, Maria del Carmen Sandi Perez, Patrick Aebischer, Maurizio Molinari, Maria Isabel Cordero Campana, Jean-Charles Bensadoun, Nicolas Bouche, Veronica Setola, Osiris Marroquin Belaunzaran

BACKGROUND: Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current pri ...

Public Library of Science2011

Dynamic fragmentation of ceramics, signature of defects and scaling of fragment sizes

Jean-François Molinari, Sarah Levy

Defects play a critical role in the dynamic fragmentation process of structural ceramics. Cracks initiate at seemingly random locations, propagate and coalesce to form fragments. The process is accompanied by stress release waves, whose influence is diffic ...

Elsevier2010

Strategies to prolong the plasma residence time of peptide drugs

Christian Heinis, Lisa Pollaro

Peptides are an attractive class of molecules for the development of therapeutics because they combine unique properties such as high binding affinity, excellent target specificity, low toxicity and a relatively small mass. However, the short in vivo half- ...

2010

Enantioselective Synthesis of the Sporolide Quinone Acid Fragment

Karl Gademann, Jean-Yves Wach

The sporolide quinone acid is a key fragment in the biosynthesis of the complex heptacyclic marine metabolite sporolide. We report a concise enantioselective route to this fragment, which is obtained in seven steps with 65% overall yield from trimethoxyben ...

2009

Photodissociation of Alkyl Iodides in Helium Nanodroplets III: Recombination

Marcel Drabbels, Andreas Braun

The recombination of fragments resulting from the photodissociation of (fluorinated) alkyl iodides in helium nanodroplets at a wavelength of 266 nm has been investigated by means of ion imaging techniques. It is found that in the case of CH3I an appreciabl ...

2007

Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor

David Michael Suter

Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylatio ...

American Society for Biochemistry and Molecular Biology2007

Cellular photoperception and photoactive proteins

Majed Chergui, Stefan Haacke

A review. The crucial steps of cellular photoperception are characterized and followed in real time by laser spectroscopy down to a few tens of femtoseconds. The photoactive proteins studied here are involved in major natural processes such as vision (bact ...

2007

Anti-cooperativity in diffusion-controlled reactions with pairs of anisotropic domains: a model for the antigen-antibody encounter

Paolo De Los Rios, Francesco Piazza

The encounter between anisotropic agents in diffusion-controlled reactions is a topic of very general relevance in chemistry and biology. Here we introduce a simplified model of encounter of an isotropic molecule with a pair of partially reacting agents an ...

Springer-Verlag2005

Peptide and protein characterization by high-rate electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry. [Erratum to document cited in CA142:280385]

Yury Tsybin

A review. On page 723, the equation should read: M + zH+.bul.: [M + zH]Z+ + e -> M + zH+.bul. (+6 eV) -> M + (z - 1)H+ + H.* -> fragments. [on SciFinder (R)] ...

2004

A heterobimetallic rhodium(I)-ruthenium(II) catalyst for the Oppenauer-type oxidation of primary and secondary alcohols under mild conditions

Kay Severin, Sébastien Gauthier

A heterobimetallic complex, in which a RuCl2(acetone) (PPh3)(2) fragment is connected via three chloro bridges to a (eta(4)-C4Ph4CO)RhCl fragment, has been identified as a potent catalyst precursor for the Oppenauer-type oxidation of alcohols. With 0.1-0.5 ...

2004

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