Publications related to Substrate (chemistry)

Recording physiological history of cells with chemical labeling

Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular events for later analysis. We designed proteins t ...

Amer Assoc Advancement Science2024

A molecular device for the redox quality control of GroEL/ES substrates

Camille Véronique Bernadette Goemans

Hsp60 chaperonins and their Hsp10 cofactors assist protein folding in all living cells, constituting the paradigmatic example of molecular chaperones. Despite extensive investigations of their structure and mechanism, crucial questions regarding how these ...

2023

Flowing Gas Experiments Reveal Mechanistic Details of Interfacial Reactions on a Molecular Level at Knudsen Flow Conditions

Christian Ludwig, Michel Rossi, Riccardo Iannarelli

Knudsen flow experiments and its interpretation in terms of adsorption/desorption kinetics as well as quantitative uptake on substrates of interest is presented together with the description of critical design parameters of the Knudsen Flow Reactor (KFR). ...

2022

Azide-Containing Hypervalent Iodine Reagents for Biomolecules Functionalization

Raphaël Michel Henri Simonet-Davin

The goal of my PhD was the development of a new method for unselective surface labeling, not substrate-specific, that would give access to direct visualization of any surface interactions.In order to achieve this challenging goal, we wanted to develop a ge ...

EPFL2022

Radical Alkynylations with EthynylBenziodoXolones: From Photocatalysis to Direct Excitation

Jérôme Waser, Stephanie Grace Elizabeth Amos

Ethynylbenziodoxolones (EBXs) have recently emerged as potent reagents for the alkynylation of radicals. Their combination with photocatalysis allows the synthesis of valuable alkynes at room temperature. Herein, we discuss two photomediated strategies for ...

SWISS CHEMICAL SOC2022

Article Structure and functionality of a multimeric human COQ7:COQ9 complex

Matteo Dal Peraro, Luciano Andres Abriata

Coenzyme Q (CoQ) is a redox-active lipid essential for core metabolic pathways and antioxidant defense. CoQ is synthesized upon the mitochondrial inner membrane by an ill-defined "complex Q" metabolon. Here, we present structure-function analyses of a lipi ...

CELL PRESS2022

Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA

Gabriela Garcia Rodriguez

The rnlAB toxin-antitoxin operon from Escherichia co/ifunctions as an anti-phage defense system. RnlA was identified as a member of the HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding domain) superfamily of ribonucleases. The activity of the tox ...

OXFORD UNIV PRESS2021

The mRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor

Yimon Aye, Jesse Poganik, Yi Zhao, Alexandra Krina Van Hall-Beauvais

The key mRNA-binding proteins HuR and AUF1 are reported stress sensors in mammals. Intrigued by recent reports of sensitivity of these proteins to the electrophilic lipid prostaglandin A2 and other redox signals, we here examined their sensing abilities to ...

2020

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Substrate (chemistry)

Revealing chromatin-specific functions of histone deacylases

Recording physiological history of cells with chemical labeling

A molecular device for the redox quality control of GroEL/ES substrates

Flowing Gas Experiments Reveal Mechanistic Details of Interfacial Reactions on a Molecular Level at Knudsen Flow Conditions

Azide-Containing Hypervalent Iodine Reagents for Biomolecules Functionalization

Radical Alkynylations with EthynylBenziodoXolones: From Photocatalysis to Direct Excitation

Article Structure and functionality of a multimeric human COQ7:COQ9 complex

Stabilizing Unusual Oxidation States of Lanthanides in Molecular Complexes: Synthesis, Properties, and Reactivity

Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA

The mRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor

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Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA

Stabilizing Unusual Oxidation States of Lanthanides in Molecular Complexes: Synthesis, Properties, and Reactivity

Flowing Gas Experiments Reveal Mechanistic Details of Interfacial Reactions on a Molecular Level at Knudsen Flow Conditions

Azide-Containing Hypervalent Iodine Reagents for Biomolecules Functionalization

The mRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor

Article Structure and functionality of a multimeric human COQ7:COQ9 complex

Revealing chromatin-specific functions of histone deacylases

Radical Alkynylations with EthynylBenziodoXolones: From Photocatalysis to Direct Excitation