Concept
DNA repair
Related publications (615)
Ultrafast carrier dynamics and insights in defect mechanism of p-type colloidal ZnO QDs
Jacques-Edouard Moser, Andrea Cannizzo, Etienne Christophe Socie, Camila Bacellar Cases Da Silveira, Victoria Kabanova
In this study, we place a strong emphasis on understanding the ultrafast dynamics of carrier recombination pathways in p-type ZnO, especially in the midgap region. Synthesizing and controlling the properties of p-type ZnO remains a pivotal yet challenging ...
SPIE2024Telomere protection against oxidative stress
Telomeres are nucleoprotein structures at the ends of linear chromosomes, being essential for the maintenance of genomic integrity. Telomeres have a unique structure which distinguishes chromosome termini from DNA damage sites. Shelterin complexes are the ...
EPFL2023Preomic profile of BxPC-3 cells after treatment with BRC4
BRCA2 and RAD51 are two proteins that play a central role in homologous recombination (HR) and DNA double strand break (DSB) repair. BRCA2 assists RAD51 fibrillation and defibrillation through binding with its eight BRC repeats, with BRC4 being one of the ...
ELSEVIER2023Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome
John McKinney, Neeraj Dhar, Zela Alexandria-Mae Martin
A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encoded 'mycobacterial ...
Cambridge2023Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis
Maria del Carmen Sandi Perez, Mandy Meijer
DNA methylation (DNAm) is one of the most frequently studied epigenetic mechanisms facilitating the interplay of genomic and environmental factors, which can contribute to externalizing behaviours and related psychiatric disorders. Previous epigenome-wide ...
PERGAMON-ELSEVIER SCIENCE LTD2023Regulation and impact of TERRA R-loops at human telomeres
Telomeres are the nucleoprotein structures found at the ends of linear chromosomes. They ensure that the termini of chromosomes are not inappropriately recognized as sites of DNA damage, and are therefore crucial for genome stability. In spite of the heter ...
EPFL2023Urtica dioica Leaf Infusion Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Cisplatin Treatment
Urtica dioica (UD) has been widely used in traditional medicine due to its therapeutic benefits, including its anticancer effects. Natural compounds have a promising potential when used in combination with chemotherapeutic drugs. The present study explores ...
MDPI2023SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase
Didier Trono, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Béatrice Kunz, Audrey Geneviève Chuat, Joana Carlevaro Fita, Nattawadee Panyain
SARS-CoV-2 infection requires Spike protein-mediated fusion between the viral and cellular membranes. The fusogenic activity of Spike depends on its post-translational lipid modification by host S-acyltransferases, predominantly ZDHHC20. Previous observati ...
2023Development of multiplexed single-molecule imaging techniques to study chromatin invasion dynamics of chromatin effector proteins
DNA-binding proteins physically interact with the DNA and directly affect genomic functions. The eukaryotic genome is compacted into chromatin, limiting the DNA access to nuclear factors. In this Ph.D. thesis, I explored the dynamic mechanisms, that allow ...
EPFL2023Repair! Reclaiming Berlin’s Workers’ Housing through Collaborative Transformation
The phase of economic and humanitarian emergencies after the Great War functioned as a laboratory for architects to develop quick, rational responses. But socialist visions became stuck in privatization, and values of a bygone society were maintained by pr ...
2023