Publications related to Bile | EPFL Graph Search

A microbial-derived succinylated bile acid to safeguard liver health

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny

In this issue of Cell, Nie and co-authors report that the microbe-derived bile acid (BA) 3-succinylated cholic acid protects against the progression of metabolic dysfunction-associated liver disease. Intriguingly, its protective mechanism does not involve ...

Cell Press2024

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

Henning Paul-Julius Stahlberg, Dongchun Ni

BSEP (ABCB11) is an ATP-binding cassette transporter that is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. BSEP dysfunction, caused by mutations or induced by drugs, is frequently associated with severe cholestatic live ...

Berlin2023

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Bart Deplancke, Wouter Saelens

The liver is the largest solid organ in the body, yet it remains incompletely characterized. Here we present a spatial proteogenomic atlas of the healthy and obese human and murine liver combining single-cell CITEseq, single-nuclei sequencing, spatial tran ...

CELL PRESS2022

Molecular physiology of bile acid signaling in health, disease, and aging

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Laura Alejandra Velazquez Villegas

Over the last two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by the gut microbio ...

2021

Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity

Kristina Schoonjans, Alessia Perino

Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implic ...

CELL PRESS2021

Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology

Kristina Schoonjans, Hadrien Charles Edouard Demagny, Yu Sun

Nuclear receptors play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. The nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2), originally identified in the live ...

2021

Bioavailability of steroid hormones sorbed on microplastics for aquatic organisms through biological fluids

Florian Frédéric Vincent Breider, Thibault Béranger Masset, Cécilia Laetitia Carla Siri, Yang Liu

Many studies have reported that hydrophobic organic contaminants have the ability to sorb on microplastics in aquatic ecosystem via different mechanisms of sorption. However, a lack of studies investigating desorption of such contaminants in organism fluid ...

2020

Biogeography of microbial bile acid transformations along the murine gut

Rizlan Bernier-Latmani, Laure Menin, Solenne Anne Marie Marion, Lyne Desharnais

Bile acids, which are synthesized from cholesterol by the liver, are chemically transformed along the intestinal tract by the gut microbiota, and the products of these transformations signal through host receptors, affecting overall host health. These tran ...

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2020

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Kristina Schoonjans, Giovanni Sorrentino

Glucagon-like peptide 1 (GLP-1) mimetics are effective drugs for treatment of type 2 diabetes, and there is consequently extensive interest in increasing endogenous GLP-1 secretion and L-cell abundance. Here we identify G-protein-coupled bile acid receptor ...

AMER DIABETES ASSOC2020

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Bile

Characterization of the gut-bone marrow axis through bile acid signaling

A microbial-derived succinylated bile acid to safeguard liver health

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Molecular physiology of bile acid signaling in health, disease, and aging

Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity

Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology

Bioavailability of steroid hormones sorbed on microplastics for aquatic organisms through biological fluids

Biogeography of microbial bile acid transformations along the murine gut

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

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Chat with Graph Search

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity

Molecular physiology of bile acid signaling in health, disease, and aging

Bioavailability of steroid hormones sorbed on microplastics for aquatic organisms through biological fluids

A microbial-derived succinylated bile acid to safeguard liver health

Characterization of the gut-bone marrow axis through bile acid signaling

Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology

Biogeography of microbial bile acid transformations along the murine gut

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling