Khatlon Region (Вилояти Хатлон, Viloyati Xatlon), one of the four provinces of Tajikistan (вилоят, Viloyat), is the most populous of the four first level administrative regions. It is situated in the southwest of the country, between the Hisor (Gissar) Range in the north and the river Panj in the south and borders on Afghanistan in the southeast and on Uzbekistan in the west. During Soviet times, Khatlon was divided into Kurgan-Tyube (Qurghonteppa) Oblast (Western Khatlon) – with the Kofarnihon and Vakhsh river valleys – and Kulob Oblast (Eastern Khatlon) – with the Kyzylsu and Yakhsu river valleys. The two regions were merged in November 1992 into today's Khatlon Region (or viloyat/oblast). The capital city is Bokhtar, formerly known as Qurghonteppa and Kurgan-Tyube.
Khatlon has an area of 24,700 square kilometres and consists of 21 districts and 4 district-level cities. The total population of Khatlon in 2020 was 3,348,300, up from 2,677,251 in the 2010 population census. The population in Khatlon is mainly engaged in agriculture.
During the Soviet era, Khatlon became one of the two main cotton regions in Tajikistan, along with Sughd (Leninabad). Collectivisation of agriculture was implemented aggressively in the early 1930s, to expand cotton cultivation in Tajikistan as a whole, with particular emphasis on the southern part of the republic. The process included violations against peasants, substantial expansion of the irrigation network, and forcible resettlement of mountain peoples and people from Uzbekistan to the lowlands.
The results of this policy are to be seen in the ethnic composition of Salua oblast as well as in the fact that the Tajik population identifies themselves either as Gharmis (resettled from the mountains) or Kulobis. These groups never melted, and fought against each other during the Civil War in Tajikistan. Khatlon oblast suffered the heaviest damage in Tajikistan.
Since the conflicts leading to the civil war were never really resolved, tensions in the region still exist.