Concept

Primary sclerosing cholangitis

Related publications (13)

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

Henning Paul-Julius Stahlberg, Dongchun Ni

BSEP (ABCB11) is an ATP-binding cassette transporter that is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. BSEP dysfunction, caused by mutations or induced by drugs, is frequently associated with severe cholestatic live ...

Berlin2023

Hysteretic behaviour of welded connections with highly inelastic panel zones

Dimitrios Lignos, Andronikos Skiadopoulos

The current practice in capacity-designed steel moment resisting frames (MRFs) worldwide allows for limitedshear yielding in the column web panel zone. As such, inelastic deformations concentrate near the beam ends, thereby leading to flexural stre ...

Ernst & Sohn2023

Biogeography and biochemistry of bile acid 7-dehydroxylation in the mammalian gut

Solenne Anne Marie Marion

Bile acids (BAs) are small molecules synthesized by the host and chemically modified by the microorganisms inhabiting the intestinal tract. The microbial transformation of BAs in the gut is critical to BA-mediated signaling as it modifies their amount and ...

EPFL2020

Biogeography of microbial bile acid transformations along the murine gut

Rizlan Bernier-Latmani, Laure Menin, Solenne Anne Marie Marion, Lyne Desharnais

Bile acids, which are synthesized from cholesterol by the liver, are chemically transformed along the intestinal tract by the gut microbiota, and the products of these transformations signal through host receptors, affecting overall host health. These tran ...

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2020

High-Performance Lead-Free Solar Cells Based on Tin-Halide Perovskite Thin Films Functionalized by a Divalent Organic

Shaik Mohammed Zakeeruddin, Felix Thomas Eickemeyer, Yuhang Liu, Min Chen

Tin-based halide perovskite solar cells (PSCs) hold the most promise among lead-free PSCs, but they are plagued with inadequate environmental stability and power-conversion efficiency (PCE). Here we demonstrate that the optimum incorporation of a bulky div ...

2020

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver

Kristina Schoonjans

TGR5 (Gpbar1) is a G protein-coupled receptor responsive to bile acids (BAs), which is expressed in different non-parenchymal cells of the liver, including biliary epithelial cells, liver-resident macrophages, sinusoidal endothelial cells (LSECs), and acti ...

2019

Polyphenic trait promotes liver cancer in a model of epigenetic instability

Didier Trono, Evaristo Jose Planet Letschert, Sandra Eloise Kjeldsen, Alessandra Piersigilli, Marco Cassano, Suk Min Jang

Hepatocellular carcinoma (HCC) represents the fifth most common form of cancer worldwide and carries a high mortality rate due to lack of effective treatment. Males are eight times more likely to develop HCC than females, an effect largely driven by sex ho ...

Wiley-Blackwell2017

Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats

Sonia Karaz, Anirikh Chakrabarti, Mojgan Masoodi, Alice Pannerec, Jay Siddharth

The microbiome has been demonstrated to play an integral role in the maintenance of many aspects of health that are also associated with aging. In order to identify areas of potential exploration and intervention, we simultaneously characterized age-relate ...

Impact Journals Llc2017

Intestinal bacteria induce TSLP to promote mutualistic T-cell responses

Nicola Harris, Mario Michael Zaiss, Ilaria Mosconi

Thymic stromal lymphopoietin (TSLP) is constitutively expressed in the intestine and is known to regulate inflammation in models of colitis. We show that steady-state TSLP expression requires intestinal bacteria and has an important role in limiting the ex ...

Nature Publishing Group2013

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output

Kristina Schoonjans

Chronic cholangiopathies have limited therapeutic options and represent an important indication for liver transplantation. The nuclear farnesoid X receptor (FXR) and the membrane G protein-coupled receptor, TGR5, regulate bile acid (BA) homeostasis and inf ...

2011

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