Concept

The dose makes the poison

Related publications (23)

In vivo anti-tumor activity of the organometallic ruthenium(II)-arene complex [Ru(eta(6)-p-cymene)-Cl-2(pta)] (RAPTA-C) in human ovarian and colorectal carcinomas

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Maxime Dubois

Based on the clinical success of platinum-based anti-cancer drugs such as cisplatin, carboplatin and oxaliplatin, a variety of other metal-based anti-cancer compounds are being investigated. In particular, a number of ruthenium-based compounds have been id ...

2014

Helium-induced hardening effect in ferritic/martensitic steels F82H and Optimax-A irradiated in a mixed spectrum of high energy protons and spallation neutrons

Yong Dai

Ferritic/martensitic (FM) steels, F82H and Optimax-A, were irradiated up to 11.3 dpa/1175 appm He in Target-3 of the Swiss Spallation Neutron Source (SINQ). To investigate helium-induced hardening effect, micro-hardness and microstructure of the irradiated ...

Elsevier2011

A secondary metabolite acting as a signalling molecule controls Pseudomonas entomophila virulence

Bruno Lemaitre, Onya Opota

Pseudomonas entomophila is an entomopathogenic bacterium that is lethal to Drosophila melanogaster within 1-2 days of ingestion of high doses. Flies orally infected with P. entomophila rapidly succumb despite the induction of both local and systemic immune ...

Wiley-Blackwell2010

Irradiation creep and microstructural changes in an advanced ODS ferritic steel during helium implantation under stress

Manuel Alexandre Pouchon, Wolfgang Hoffelner

An advanced oxide dispersion strengthened (ODS) ferritic steel with very fine oxide particles has been homogeneously implanted with helium under uniaxial tensile stresses from 20 to 250 MPa to a maximum dose of about 0.38 dpa (1650 appm-He) with displaceme ...

Elsevier2009

Irradiation creep and precipitation in a ferritic ODS steel under helium implantation

Manuel Alexandre Pouchon, Wolfgang Hoffelner

Ferritic oxide dispersion strengthened (ODS) steel, PM2000, has been homogeneously implanted with helium under uniaxial tensile stresses from 20 to 250 MPa to maximum doses of about 0.75 dpa (3000 ppm He) with displacement damage rates of 5.5 × 10−6 dpa/s ...

Elsevier2008

Nuclear responses in IFMIF creep-fatigue testing machine

The International Fusion Materials Irradiation Facility (IFMIF) is an intense high-energy neutron source dedicated to the development and qualification of materials for the first generation of fusion reactors. The target facility will consist of a high flu ...

Elsevier2008

First in vivo MRI assessment of a self-assembled metallostar compound endowed with a remarkable high field relaxivity

André Merbach, Lothar Helm, Eva Jakab Toth, Joao Bruno Livramento Fig.

{Fe[Gd2bpy(DTTA)2(H2O)4]3}4- is a self-assembled, metallostar-structured potential MRI contrast agent, with six efficiently relaxing Gd3+ centers confined into a small mol. space. Its proton relaxivity is particularly remarkable at very high magnetic field ...

2006

Ink-Jetting of Polymers and Biomaterials

Jürgen Brugger, Vahid Fakhfouri, Kristopher Pataky, Yun Luo

Inkjet printing is a very common and largely developed technology in desktop printers. A wide range of diverse technologies, with different principles of drop generation, fall into the inkjet printing category. Inkjet technology, particularly the drop-on-d ...

2005

Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

Patrick Aebischer

Glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophic factor with restorative effects in a variety of rodent and primate models of Parkinson's disease (PD), could be of therapeutic value to PD. In this study, we show that intraventricul ...

2004

From toxic releases to damages on human health

Pierre Crettaz

Life Cycle Assessment (LCA) is a tool developed to evaluate the environmental impact of a product or a system. After a decade of research in the LCA field, significant progress has been achieved but methodologies for the assessment of toxicological impacts ...

EPFL2001

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