Menstrual cycle | EPFL Graph Search

The menstrual cycle is a series of natural changes in hormone production and the structures of the uterus and ovaries of the female reproductive system that makes pregnancy possible. The ovarian cycle controls the production and release of eggs and the cyclic release of estrogen and progesterone. The uterine cycle governs the preparation and maintenance of the lining of the uterus (womb) to receive an embryo. These cycles are concurrent and coordinated, normally last between 21 and 35 days, with a median length of 28 days, and continue for about 30–45 years. Naturally occurring hormones drive the cycles; the cyclical rise and fall of the follicle stimulating hormone prompts the production and growth of oocytes (immature egg cells). The hormone estrogen stimulates the uterus lining (endometrium) to thicken to accommodate an embryo should fertilization occur. The blood supply of the thickened lining provides nutrients to a successfully implanted embryo. If implantation does not occur,

THERMOECONOMIC ANALYSIS AND OPTIMISATION OF AIR-BASED BOTTOMING CYCLES FOR WATER-FREE HYBRID SOLAR GAS-TURBINE POWER PLANTS

Raphaël Michel Adrien Marie Sandoz

Among the plethora of alternatives available, concentrated solar power (CSP) appears as one of the most favourable options. The stability and dispatchability of production achievable by the integration of storage and fuel-solar hybridisation are amidst the major advantages of this technology. Nevertheless, conventional CSP plants are based on stream-turbine cycles which consume large amounts of water. In addition to the low thermodynamic efficiency of this type of cycle, the installation of such plants in water-scarce areas is complicated by their reliance on water resources. Thus, the study of new concepts that overcome these drawbacks is necessary for the future of this technology. The availability of high temperature solar receivers for solar tower systems opens the way for the use of gas-turbines in hybrid solar- natural gas configurations. In order to increase the efficiency of the cycle while keeping the water consumption as low as possible, a promising alternative to the recovery of the waste heat in steam-turbines is to use a low-temperature intercooled-recuperated gas-turbine cycle. This work focuses on the analysis and optimisation of the performance of an innovative hybrid solar gas-turbine power plant with an air-based bottoming cycle (ABHSGT). The evaluation considers thermodynamic performance, economic viability and environmental impact as interrelated concerns. With this in mind, detailed steady-state and dynamic models of the power plant have been developed and validated by comparison with existing components. A second model without bottoming cycle has been built for comparison. A multi-objective optimisation using an evolutionary algorithm has then been performed, optimising both capital cost and specific CO2 emissions and resulting in a Pareto-optimal set of possible designs. The analysis of the trade-off curves resulting from the optimisation reveals promising outcomes. The global minimum for the levelised cost of electricity, found at relatively high solar shares, proves the economic potential of the technology. The integration of the bottoming cycle decreases significantly the levelised cost of electricity and the CO2 emissions of the system compared to the reference plant, and higher efficiencies are achieved. The optimal design selected for an in-depth thermoeconomic and environmental analysis exhibits a levelised cost of electricity of 109 [USD/MWhe] for a solar share of 20% and an overall exergetic efficiency 38.5%. The specific CO2 emissions are reduced by 33% compared to those of a simple gas-fired power plant. The water consumption is kept at very low levels compared to other CSP plants, making the system suitable for the deployment in water-scarce areas. In addition, the environmental impact induced by the land use requirements is considerably lower than that of other renewable energy technologies. The sensitivity analysis performed to assess the consequence of changes in varying financial conditions on the levelised cost of electricity and the net present value reveals that the system studied represents a profitable investment in the presence of feed-in tariffs. In the light of the performance obtained in the three aspects considered (thermodynamic, economic and environmental), it can be concluded that the ABHSGT represents a promising alternative to other renewable energy technologies, especially in water-scarce areas.

2012

Progestins used for hormonal contraception in Switzerland: study of their effects on the breast epithelium

Marie Shamseddin

Breast cancer is the most commonly diagnosed cancer and the most common cause of cancer death among women. Hormones have been shown to have a key role in breast development and carcinogenesis. Repeated activation of progesterone receptor (PR) signaling as it occurs during menstrual cycles is important in cancer risk. Through hormonal contraception many women are exposed to synthetic PR agonists, progestins, either on their own or in combination with the synthetic estrogen receptor (ER) agonist, ethinyl estradiol (EE). Progestins vary in their chemical structures and biological activities. Epidemiological studies show that hormonal contraceptions increase the risk of breast cancer but to date there have been few studies that analyze specific progestins regarding the breast cancer risk they confer. We hypothesized that different progestins have distinct abilities to induce cell proliferation and to modulate gene expression in the breast epithelium and this may ultimately have different effects on breast cancer risk. To test the hypothesis that different progestins currently used in hormonal contraceptions in Switzerland have distinct abilities to induce the expression of important mediators of PR action, receptor activator of NF-ÎºB ligand (RANKL) and Wnt4, we employed mouse mammary gland organoids and human breast tissue microstructures. We find that androgenic progestins strongly induce RANKL and Wnt4 whereas anti-androgenic progestins fail to do so. To test the ability of different progestins currently used in hormonal contraceptions in Switzerland to induce cell proliferation in human breast epithelium, we humanized mouse mammary gland using intraductal injection of human breast epithelial cells obtained from reduction mammoplasty surgery. We show that breast epithelial cells maintain hormone receptor expression and remain hormone responsive in this approach. We find that the androgenic progestins, Gestodene and Levonorgestrel, promote cell proliferation over two months more than progesterone. Furthermore, we show that Androgen receptor (AR) inhibition abrogates promegestone-induced RANKL induction and reduces cell proliferation induced by androgenic progestin, LNG. We also show that activation of AR signaling through DHT exposure is sufficient to induce proliferation of human breast epithelial cells. Thus, different progestins have different biological effects on the breast epithelium that appear to be related to their androgenic activities.

EPFL2018

Microfluidic Platform for Seawater Desalination by Coulometric Removal of Chloride Ions through Printed Ag Electrodes

Marianna Fighera, Herbert Shea, Peter Van der Wal

This paper reports on the electrochemical characterization and comparison of printable silver inks for the fabrication of planar electrodes to integrate in a microfluidic platform for in situ desalination of seawater prior to detection of nutrients in marine environment. Screen printing and inkjet printing were investigated to overcome limitations of more conventional deposition techniques. The screen printed ink DuPont 5064H was chosen for the fabrication of the desalination platform as it displayed the best properties in terms of oxidation ability (15.5 mC/mm(2)) and absence of sample contamination. The platform was tested at different oxidation conditions; the optimum potential for desalination was found to be +0.9 V. The device desalination performance was then evaluated through conductivity measurements of the treated sample and a proof-of-concept was achieved: for a potential of +0.9 V, conductivity (hence concentration) could be lowered from an initial value of 42.13 mS (0.6 M) to 20.36 mS (0.206 M), 17.37 mS (0.157 M) and 6.38 mS (0.0516 M) for oxidation times of 120 s, 240 s and 360 s, respectively. The operating conditions allowed the regeneration of the silver electrode and the possibility to deploy it for six to ten cycles before depletion of the silver working electrode. (C) 2017 The Electrochemical Society. All rights reserved.